2015
The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users
Jones JD, Sullivan MA, Manubay JM, Mogali S, Metz VE, Ciccocioppo R, Comer SD. The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users. Physiology & Behavior 2015, 159: 33-39. PMID: 26455893, PMCID: PMC5444321, DOI: 10.1016/j.physbeh.2015.10.006.Peer-Reviewed Original ResearchConceptsEffect of pioglitazoneAbuse liabilityOpioid usersOpioid agonist effectsGood drug effectEffects of opioidsAbility of pioglitazoneActivation of PPARγPrescription opioid abusersDose-dependent increaseAddictive-like responsePositive subjective responsesMaintenance doseDaily dosesOpioid abusersOpioid receptorsPain perceptionReceptor agonistAgonist effectsDrug effectsOxycodonePioglitazoneRespiratory rateOpioidsCognitive effects
2012
Polydrug abuse: A review of opioid and benzodiazepine combination use
Jones JD, Mogali S, Comer SD. Polydrug abuse: A review of opioid and benzodiazepine combination use. Drug And Alcohol Dependence 2012, 125: 8-18. PMID: 22857878, PMCID: PMC3454351, DOI: 10.1016/j.drugalcdep.2012.07.004.Peer-Reviewed Original Research
2011
Chronic pain, Addiction severity, and misuse of opioids in Cumberland County, Maine
Heimer R, Dasgupta N, Irwin KS, Kinzly M, Harvey AP, Givens A, Grau LE. Chronic pain, Addiction severity, and misuse of opioids in Cumberland County, Maine. Addictive Behaviors 2011, 37: 346-349. PMID: 22138379, DOI: 10.1016/j.addbeh.2011.11.017.Peer-Reviewed Original ResearchConceptsAddiction Severity IndexBrief Pain InventoryChronic painOpioid abuseBPI scoresMisuse of opioidsCommon co-occurring conditionsSubstance abuse treatment programsCommunity-based sampleCo-occurring conditionsSubstance abuse treatmentStreet-recruited sampleOrder of onsetRespondent-driven samplingPain InventoryPain managementIllicit opioidsOpioid misuseRegular physicianOpioid abusersDaily livingPainDrug misusePrior monthTreatment program
1988
Clinical Utility of Rapid Clonidine‐naltrcxone Detoxification for Opioid Abusers
VINING E, KOSTEN T, KLEBER H. Clinical Utility of Rapid Clonidine‐naltrcxone Detoxification for Opioid Abusers. Addiction 1988, 83: 567-575. PMID: 3382815, DOI: 10.1111/j.1360-0443.1988.tb02576.x.Peer-Reviewed Original ResearchConceptsNaltrexone therapyAbrupt opioid withdrawalSingle morning dosesEffects of naltrexoneNaloxone challenge testMorning dosesOpioid withdrawalBlood pressureOpioid dependenceSingle doseMean doseNaltrexone dosesOpioid abusersClinical utilityEffective treatmentClinical problemClonidine hydrochlorideDay 1Heroin usersDay 2Challenge testHydrochloride treatmentNaltrexone hydrochlorideThird dayFirst day
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