2020
Challenges in use of saliva for detection of SARS CoV-2 RNA in symptomatic outpatients
Landry ML, Criscuolo J, Peaper DR. Challenges in use of saliva for detection of SARS CoV-2 RNA in symptomatic outpatients. Journal Of Clinical Virology 2020, 130: 104567. PMID: 32750665, PMCID: PMC7392849, DOI: 10.1016/j.jcv.2020.104567.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingCOVID-19 VaccinesHumansMolecular Diagnostic TechniquesNasopharynxOutpatientsPandemicsPneumonia, ViralProspective StudiesReal-Time Polymerase Chain ReactionRNA, ViralSalivaSARS-CoV-2Specimen HandlingConceptsNasopharyngeal swabsReal-time RT-PCRSymptomatic outpatientsRT-PCRSARS-CoV-2 positivitySaliva samplesSARS-CoV-2 testingMedian cycle threshold valuePure salivaSARS-CoV-2 RNA detectionSARS-CoV-2 RNACoV-2 testingUse of salivaCycle threshold valuesSymptomatic patientsOverall sensitivityRNA detectionSalivaCOVID-19OutpatientsHigh-volume testingPatientsSwabs
2017
Analytical Validation of the Next-Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trial Molecular Analysis for Therapy Choice Clinical Trial
Lih CJ, Harrington RD, Sims DJ, Harper KN, Bouk CH, Datta V, Yau J, Singh RR, Routbort MJ, Luthra R, Patel KP, Mantha GS, Krishnamurthy S, Ronski K, Walther Z, Finberg KE, Canosa S, Robinson H, Raymond A, Le LP, McShane LM, Polley EC, Conley BA, Doroshow JH, Iafrate AJ, Sklar JL, Hamilton SR, Williams PM. Analytical Validation of the Next-Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trial Molecular Analysis for Therapy Choice Clinical Trial. Journal Of Molecular Diagnostics 2017, 19: 313-327. PMID: 28188106, PMCID: PMC5397672, DOI: 10.1016/j.jmoldx.2016.10.007.Peer-Reviewed Original ResearchConceptsNext-generation sequencingNational Cancer Institute-Molecular AnalysisMultiple clinical laboratoriesParaffin-embedded clinical specimensTherapy Choice (NCI-MATCH) trialClinical Laboratory Improvement AmendmentsNext-generation sequencing assayPrecision medicine studiesStandard treatmentRefractory cancerClinical trialsBiopsy collectionClinical specimensPanel assayClinical useOverall sensitivityMedicine studiesPairwise concordanceReportable variantsCompliant useNGS assaysTrialsPrecision medicineCell linesClinical laboratories
2015
Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma
Nguyen T, Phillips D, Jain D, Torbenson M, Wu TT, Yeh MM, Kakar S. Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma. Archives Of Pathology & Laboratory Medicine 2015, 139: 1028-34. PMID: 26230595, DOI: 10.5858/arpa.2014-0479-oa.Peer-Reviewed Original ResearchConceptsHep Par 1Polyclonal carcinoembryonic antigenArginase-1Hepatocellular carcinomaGlypican-3Carcinoembryonic antigenPAR-1Immunohistochemical markersSensitive markerHepatocellular differentiationLiver biopsyCarcinomaBest overall sensitivityHepatocellular markersLimited tissueAntigen 1Overall sensitivityDiagnosisCombined useReliable diagnosisPositive resultsMarkersLimited role
2011
Potassium channel modulation and auditory processing
Brown MR, Kaczmarek LK. Potassium channel modulation and auditory processing. Hearing Research 2011, 279: 32-42. PMID: 21414395, PMCID: PMC3137660, DOI: 10.1016/j.heares.2011.03.004.Peer-Reviewed Original ResearchConceptsAuditory brainstem nucleiBrainstem nucleiPotassium channelsPotassium channel modulationSynaptic stimulationFiring patternsOverall sensitivityChannel modulationNeuronsAuditory environmentAuditory processingAuditory systemHigh rateAuditory informationIntrinsic electrical propertiesKey proteinsReview article
2007
Flow cytometric analysis of myelomonocytic cells by a pattern recognition approach is sensitive and specific in diagnosing myelodysplastic syndrome and related marrow diseases: Emphasis on a global evaluation and recognition of diagnostic pitfalls
Stachurski D, Smith BR, Pozdnyakova O, Andersen M, Xiao Z, Raza A, Woda BA, Wang A. Flow cytometric analysis of myelomonocytic cells by a pattern recognition approach is sensitive and specific in diagnosing myelodysplastic syndrome and related marrow diseases: Emphasis on a global evaluation and recognition of diagnostic pitfalls. Leukemia Research 2007, 32: 215-224. PMID: 17675229, DOI: 10.1016/j.leukres.2007.06.012.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeFlow cytometryDiagnostic pitfallsMyelomonocytic cellsMDS/MPDClonal cytogenetic abnormalitiesGlobal evaluationImmunophenotypic aberranciesRetrospective reviewMorphological dysplasiaMarrow diseaseMyeloproliferative diseaseDiagnostic utilityCytogenetic abnormalitiesDisease casesMyeloid diseasesCytometric analysisOverall sensitivityAbnormalitiesDiseaseOverall abnormalitySyndromeIntermediate category
2004
Experienced paramedics cannot inflate or estimate endotracheal tube cuff pressure using standard techniques
Parwani V, Hahn I, Hoffman R. Experienced paramedics cannot inflate or estimate endotracheal tube cuff pressure using standard techniques. Annals Of Emergency Medicine 2004, 44: s64. DOI: 10.1016/j.annemergmed.2004.07.211.Peer-Reviewed Original ResearchEndotracheal tube cuff pressureTube cuff pressureEndotracheal tube cuffTube cuffCuff pressureEndotracheal tubeHigh-volume low-pressure cuffsAverage cuff pressureStandard palpation techniqueLow-pressure cuffsCapillary perfusion pressureExperienced paramedicsPilot balloonPerfusion pressureTracheal necrosisSafe pressureInflated cuffPalpation techniqueCuffOverall sensitivityLuer lockParamedicsStandard techniquesBalloonDescriptive survey
2001
Hepatocellular Carcinoma and Dysplastic Nodules in Patients with Cirrhosis: Prospective Diagnosis with MR Imaging and Explantation Correlation
Krinsky G, Lee V, Theise N, Weinreb J, Rofsky N, Diflo T, Teperman L. Hepatocellular Carcinoma and Dysplastic Nodules in Patients with Cirrhosis: Prospective Diagnosis with MR Imaging and Explantation Correlation. Radiology 2001, 219: 445-54. PMID: 11323471, DOI: 10.1148/radiology.219.2.r01ma40445.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaDysplastic nodulesMR imagingHistory of HCCSpecificity of MRDetection of HCCMagnetic resonanceDiagnosis of tumorsHepatic arterialHepatic malignanciesPathologic resultsHepatic neoplasmsProspective diagnosisGradient-echo MR imagesMR image interpretationPatient basisLesion basisMR imagesPatientsSubsequent transplantationSpin-echo MR imagesLesions 1Overall sensitivity
1993
The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency
Green B, Shaffer G. The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency. Pain 1993, 53: 323-334. PMID: 8351161, DOI: 10.1016/0304-3959(93)90228-h.Peer-Reviewed Original ResearchConceptsInter-stimulus intervalTopical exposureIntensity of itchingUse of capsaicinApplication of capsaicinHand-held dynamometerDuration of sensitizationSensations of itchingTest 24 hFifth exposureDay 1Day 2Sensory irritationCapsaicinItchingOverall sensitivityDesensitizationLess sensitizationSensitizationSensory responsesMarked individual differencesTime courseDifferential effectsItchPungent sensation
1983
Tomographic Gallium-67 Citrate Scanning Useful New Surveillance for Metastatic Melanoma
KIRKWOOD J, MYERS J, VLOCK D, NEUMANN R, ARIYAN S, GOTTSCHALK A, HOFFER P. Tomographic Gallium-67 Citrate Scanning Useful New Surveillance for Metastatic Melanoma. Annals Of Surgery 1983, 198: 102-107. PMID: 6859984, PMCID: PMC1352941, DOI: 10.1097/00000658-198307000-00020.Peer-Reviewed Original ResearchConceptsLymph nodesMetastatic melanomaTomographic scanBone sitesEvident lymph nodesIndependent clinical evaluationProspective surveillance studyPeripheral lymph nodesSoft tissue sitesLymphatic sitesMediastinal sitesGallium scanGallium imagingPulmonary sitesClinical evaluationTomographic scanningAbdominal sitesGallium uptakeBrain sitesOsseous sitesSurveillance studyDiscordant findingsTissue sitesOverall sensitivityMelanoma
1982
Tomographic gallium-67 citrate scanning: useful new surveillance for metastatic melanoma.
KIRKWOOD J, MYERS J, VLOCK D, NEUMANN R, ARIYAN S, GOTTSCHALK A, HOFFER P. Tomographic gallium-67 citrate scanning: useful new surveillance for metastatic melanoma. Annals Of Internal Medicine 1982, 97: 694-9. PMID: 7137734, DOI: 10.7326/0003-4819-97-5-694.Peer-Reviewed Original ResearchConceptsLymph nodesMetastatic melanomaTomographic scanBone sitesEvident lymph nodesIndependent clinical evaluationProspective surveillance studyPeripheral lymph nodesSoft tissue sitesLymphatic sitesMediastinal sitesGallium scanGallium imagingPulmonary sitesClinical evaluationTomographic scanningAbdominal sitesGallium uptakeBrain sitesOsseous sitesSurveillance studyDiscordant findingsTissue sitesOverall sensitivityMelanoma
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