2025
Activation of Pvt1b isoform contributes to local Pvt1 abundance to repress Myc during stress
Li Q, Olivero C, Floyd E, Ding J, Dangelmaier E, Knight J, Dimitrova N. Activation of Pvt1b isoform contributes to local Pvt1 abundance to repress Myc during stress. PLOS Genetics 2025, 21: e1011790. PMID: 40743223, PMCID: PMC12312954, DOI: 10.1371/journal.pgen.1011790.Peer-Reviewed Original ResearchConceptsTranscription start siteSequence elementsOncogenic stressLong-read sequencingP53-induced increaseIsoform-specific activitiesMYC proto-oncogeneLncRNA lociStart siteMYC regulationMyc repressionLong noncoding RNAsStress responseMYCTumor suppressionNoncoding RNAsProto-oncogeneIsoformsTranscriptionAbundanceIn vivoIn vitro modelLociPVT1Repression
2024
Titration of RAS alters senescent state and influences tumour initiation
Chan A, Zhu H, Narita M, Cassidy L, Young A, Bermejo-Rodriguez C, Janowska A, Chen H, Gough S, Oshimori N, Zender L, Aitken S, Hoare M, Narita M. Titration of RAS alters senescent state and influences tumour initiation. Nature 2024, 633: 678-685. PMID: 39112713, PMCID: PMC11410659, DOI: 10.1038/s41586-024-07797-z.Peer-Reviewed Original ResearchConceptsTumor typesOncogenic RAS-induced senescenceInfluence tumor initiationProgenitor-like featuresTumor-initiating phenotypeSingle-cell RNA sequencing analysisModel in vivoHCC subclassesModel in vitroHepatocellular carcinomaTumor suppressor mechanismEarly tumorigenesisTumor initiationEarly-onsetProgenitor featuresInduce tumorsSuppressor mechanismTumorLate-onsetRNA sequencing analysisOncogenic stressRas-induced senescenceIn vivoMolecular signaturesOncogene dosageThe Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging
Deb S, Berei J, Miliavski E, Khan M, Broder T, Akurugo T, Lund C, Fleming S, Hillwig R, Ross J, Puri N. The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging. Cells 2024, 13: 884. PMID: 38891017, PMCID: PMC11172003, DOI: 10.3390/cells13110884.Peer-Reviewed Original ResearchConceptsCigarette smoke extractNon-smokersCSE treatmentEffects of <i>inPotential biomarkersCigarette smoke exposureInduction of inflammationLung cancer developmentChronic inflammatory responseEffects of smokingIn vitro modelLung tissue samplesPotential biomarkers of agingImmunohistochemical stainingSubunit of telomeraseCancer developmentOncogenic markersInflammatory responseSmoke extractInflammatory proteinsSmoke exposureSmokersBuccal swab samplesOncogenic stressSwab samples
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