2024
The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging
Deb S, Berei J, Miliavski E, Khan M, Broder T, Akurugo T, Lund C, Fleming S, Hillwig R, Ross J, Puri N. The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging. Cells 2024, 13: 884. PMID: 38891017, PMCID: PMC11172003, DOI: 10.3390/cells13110884.Peer-Reviewed Original ResearchConceptsCigarette smoke extractNon-smokersCSE treatmentEffects of <i>inPotential biomarkersCigarette smoke exposureInduction of inflammationLung cancer developmentChronic inflammatory responseEffects of smokingIn vitro modelLung tissue samplesPotential biomarkers of agingImmunohistochemical stainingSubunit of telomeraseCancer developmentOncogenic markersInflammatory responseSmoke extractInflammatory proteinsSmoke exposureSmokersBuccal swab samplesOncogenic stressSwab samples
2017
Proteomics data on MAP Kinase Kinase 3 knock out bone marrow derived macrophages exposed to cigarette smoke extract
Srivastava R, Mannam P, Rauniyar N, Lam TT, Luo R, Lee PJ, Srivastava A. Proteomics data on MAP Kinase Kinase 3 knock out bone marrow derived macrophages exposed to cigarette smoke extract. Data In Brief 2017, 13: 320-325. PMID: 28653025, PMCID: PMC5476452, DOI: 10.1016/j.dib.2017.05.049.Peer-Reviewed Original ResearchMAP kinase kinase 3Yale Protein Expression DatabaseKinase 3Protein Expression DatabaseAbsolute quantitation (iTRAQ) reagentsIngenuity Pathway Analysis softwarePathway Analysis softwareTotal proteomeCellular proteinsIsobaric tagsProteomic dataMAP kinaseCanonical pathwaysMolecular networksCigarette smoke extractProteome DiscovererMass spectrometry dataBone marrowExpression databaseLC-MS/MSSpectrometry dataPathwaySmoke extractPhosphoproteomeProteome
2012
Retinoic Acid–related Orphan Receptor-α Is Induced in the Setting of DNA Damage and Promotes Pulmonary Emphysema
Shi Y, Cao J, Gao J, Zheng L, Goodwin A, An CH, Patel A, Lee JS, Duncan SR, Kaminski N, Pandit KV, Rosas IO, Choi AM, Morse D. Retinoic Acid–related Orphan Receptor-α Is Induced in the Setting of DNA Damage and Promotes Pulmonary Emphysema. American Journal Of Respiratory And Critical Care Medicine 2012, 186: 412-419. PMID: 22744720, PMCID: PMC5450975, DOI: 10.1164/rccm.201111-2023oc.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCells, CulturedDisease Models, AnimalDNA DamageDNA RepairGene Expression ProfilingHumansLungMiceMice, Inbred C57BLMice, Neurologic MutantsNuclear Receptor Subfamily 1, Group F, Member 1Oligonucleotide Array Sequence AnalysisPulmonary Disease, Chronic ObstructivePulmonary EmphysemaTobacco Smoke PollutionConceptsRetinoic acid-related orphan receptorAcid-related orphan receptorCigarette smoke extractLungs of patientsPathogenesis of emphysemaRORA expressionCigarette smokeAirspace enlargementSmoke extractCigarette smoke exposureSmoke-induced emphysemaOrphan receptorDNA damageActive smokingLung transplantationSmoke exposureLung cancerPulmonary emphysemaLung tissueEmphysemaPatientsGene expression profilingApoptotic cell deathMiceEnhanced susceptibility
2011
Cigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1
Zhou Y, Jorgensen EM, Gan Y, Taylor HS. Cigarette Smoke Increases Progesterone Receptor and Homeobox A10 Expression in Human Endometrium and Endometrial Cells: A Potential Role in the Decreased Prevalence of Endometrial Pathology in Smokers1. Biology Of Reproduction 2011, 84: 1242-1247. PMID: 21325691, PMCID: PMC3099588, DOI: 10.1095/biolreprod.110.087494.Peer-Reviewed Original ResearchConceptsProgesterone receptorCigarette smokeRate of endometriosisEffect of smokingCigarette smoke extractEndometrial stromal cellsExpression of HOXA10Poor health outcomesEndometrial cancerEndometrial pathologyEndometrial diseaseCigarette smokingDecreased incidenceOvarian alterationsDecreased prevalenceEndometrial tumorsEndometrial differentiationEndometrial cellsHuman endometriumSmoke extractProtective effectHomeobox A10Health outcomesHomeobox A10 expressionSmoking
2010
Cigarette smoke inhibits recruitment of bone-marrow-derived stem cells to the uterus
Zhou Y, Gan Y, Taylor HS. Cigarette smoke inhibits recruitment of bone-marrow-derived stem cells to the uterus. Reproductive Toxicology 2010, 31: 123-127. PMID: 20955787, PMCID: PMC3207965, DOI: 10.1016/j.reprotox.2010.10.007.Peer-Reviewed Original ResearchConceptsCigarette smoke extractStem cell recruitmentBone marrowCell recruitmentCigarette smokingLong-term organ damageHuman mesenchymal stem cellsStem cellsCigarette smoke exposureEndometrial epithelial cellsDecidualization markers prolactinBone marrow cellsMesenchymal stem cell recruitmentSmoking inhibitsOrgan damageSmoke exposureDecreased incidenceEndometrial cellsFemale infertilitySmoke extractUnfiltered cigarettesFemale C57BL/6JMouse modelCigarette smokeUterine sections
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