2022
Functional elements of the cis-regulatory lincRNA-p21
Winkler L, Jimenez M, Zimmer JT, Williams A, Simon MD, Dimitrova N. Functional elements of the cis-regulatory lincRNA-p21. Cell Reports 2022, 39: 110687. PMID: 35443176, PMCID: PMC9118141, DOI: 10.1016/j.celrep.2022.110687.Peer-Reviewed Original ResearchConceptsGene expression controlFull-length transcriptionDNA regulatory elementsCell cycle genesCDKN1A/p21P53-dependent expressionFunctional elementsChromatin organizationLncRNA lociNascent transcriptionRegulatory lociExpression controlCycle genesLncRNA transcriptsRegulatory elementsMolecular mechanismsTranscriptionExon 1LincRNA-p21LociP21 expressionGenetic modelsAccumulationExpressionSplicing
2018
Chapter 16 Genetic Variations of Long Noncoding RNAs in Cancer
Dimitrova N. Chapter 16 Genetic Variations of Long Noncoding RNAs in Cancer. 2018, 289-308. DOI: 10.1016/b978-0-12-811022-5.00016-4.Peer-Reviewed Original ResearchComprehensive genome analysisFunction of lncRNAsLong noncoding RNALncRNA lociCancer susceptibility variantsGenome analysisGenetic variationRegulatory regionsNoncoding RNAsGenomic dataSomatic variationExpression patternsFocal amplificationCancer predispositionPhysiological roleLncRNAsFunctional consequencesHuman cancersNucleotide polymorphismsExpression levelsRNAMechanism of actionNovel classIntriguing associationStrong linkage
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