2025
SORL1-Mediated EGFR and FGFR4 Regulation Enhances Chemoresistance in Ovarian Cancer
Jiang Z, Bi F, Ge Z, Mansolf M, Hartwich T, Kolesnyk V, Yang K, Park W, Kim D, Grechukhina O, Hui P, Kim S, Yang-Hartwich Y. SORL1-Mediated EGFR and FGFR4 Regulation Enhances Chemoresistance in Ovarian Cancer. Cancers 2025, 17: 244. PMID: 39858026, PMCID: PMC11763764, DOI: 10.3390/cancers17020244.Peer-Reviewed Original ResearchEpidermal growth factor receptorOvarian cancerRecurrent tumorsSortilin-related receptor 1Therapeutic efficacy of carboplatinResistant to conventional chemotherapyResistant ovarian cancerMolecular mechanisms of chemoresistanceCancer models in vitroEfficacy of carboplatinRecurrent ovarian cancerOvarian cancer treatmentEffective targeted therapiesMechanisms of chemoresistancePro-tumor functionsGrowth factor receptorXenograft mouse modelConventional chemotherapyStabilization of epidermal growth factor receptorModel in vitroPro-tumorEnhanced chemoresistanceCarboplatin resistanceTherapeutic efficacyFactor receptor
2024
Titration of RAS alters senescent state and influences tumour initiation
Chan A, Zhu H, Narita M, Cassidy L, Young A, Bermejo-Rodriguez C, Janowska A, Chen H, Gough S, Oshimori N, Zender L, Aitken S, Hoare M, Narita M. Titration of RAS alters senescent state and influences tumour initiation. Nature 2024, 633: 678-685. PMID: 39112713, PMCID: PMC11410659, DOI: 10.1038/s41586-024-07797-z.Peer-Reviewed Original ResearchConceptsTumor typesOncogenic RAS-induced senescenceInfluence tumor initiationProgenitor-like featuresTumor-initiating phenotypeSingle-cell RNA sequencing analysisModel in vivoHCC subclassesModel in vitroHepatocellular carcinomaTumor suppressor mechanismEarly tumorigenesisTumor initiationEarly-onsetProgenitor featuresInduce tumorsSuppressor mechanismTumorLate-onsetRNA sequencing analysisOncogenic stressRas-induced senescenceIn vivoMolecular signaturesOncogene dosageMuse stem cells: an innovative cellular model in vitro for mood and psychotic disorders study protocol
Galderisi U, Mazzoni F, Ferrara M, Saro S, Murri M, Toffanin T, Folesani F, Monteleone A, group L. Muse stem cells: an innovative cellular model in vitro for mood and psychotic disorders study protocol. Neuroscience Applied 2024, 3: 104809. DOI: 10.1016/j.nsa.2024.104809.Peer-Reviewed Original Research
2007
Combined effect of total alkaloids from Feculae Bombycis and natural flavonoids on diabetes
Geng P, Yang Y, Gao Z, Yu Y, Shi Q, Bai G. Combined effect of total alkaloids from Feculae Bombycis and natural flavonoids on diabetes. Journal Of Pharmacy And Pharmacology 2007, 59: 1145-1150. PMID: 17725858, DOI: 10.1211/jpp.59.8.0013.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAlkaloidsAnimalsBlood GlucoseBombyxCholesterolDiabetes Mellitus, ExperimentalDrug SynergismDrug Therapy, CombinationFemaleFlavonoidsGlycoside Hydrolase InhibitorsIntestinal MucosaMaleMedicine, Chinese TraditionalMicePlant ExtractsPlants, MedicinalPostprandial PeriodRatsRats, WistarStarchConceptsInhibiting alpha-glucosidase activityAlpha-glucosidase activityDiabetic mice in vivoMice in vivoBlood glucoseStarch hydrolysateFlavonoidsFasting blood total cholesterolGlucose levelsIn vivoIndividual ingredientsBlood total cholesterolFasting blood glucoseDepressed blood glucose levelsNatural flavonoidPostprandial elevationBlood glucose levelsModel in vitroTherapy of diabetesTAFBShort-term studiesTotal cholesterolOral administrationBombycisBlood
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