2024
Irpetones A and B, Anti-Osteoclastic Heptaketides from a Marine Mesophotic Zone Ircinia Sponge-Associated Fungus Irpex sp. NBUF088
Wang T, Tian J, Huang J, Yuan Y, Naman C, Wu S, Wang H, Lin W, Tong Z, Ding L, Wang W, He S. Irpetones A and B, Anti-Osteoclastic Heptaketides from a Marine Mesophotic Zone Ircinia Sponge-Associated Fungus Irpex sp. NBUF088. Journal Of Natural Products 2024, 87: 1203-1208. PMID: 38359398, DOI: 10.1021/acs.jnatprod.3c01078.Peer-Reviewed Original Research
2023
Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice
Kim H, Shim Y, Choi S, Falana T, Yoo J, Ahn S, Park M, Seo H, Choi C, Jeong W. Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice. Pharmaceutics 2023, 15: 636. PMID: 36839957, PMCID: PMC9965399, DOI: 10.3390/pharmaceutics15020636.Peer-Reviewed Original ResearchAlcohol-associated liver injuryAlcohol-associated liver diseaseInflammatory gene expression levelsInfiltration of neutrophilsKupffer cellsLiver injuryModulation of NF-kB activationActivation of Kupffer cellsGene expression levelsExpression levelsAlcohol binge drinkingNuclear translocation of NF-kBGut-derived lipopolysaccharideHepatic stellate cellsTranslocation of NF-kBNuclear factor-KBNF-kB activationEfficient therapeutic approachApoptosis of hepatocytesIntravenous injectionLiver diseaseTherapeutic approachesExosome technologyInflammatory responseStellate cells
2021
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Kim H, Lee K, Kim J, Kim M, Kim J, Lee H, Chung Y, Shin H, Kim T, Park E, Rho J, Lee S, Kim N, Lee S, Choi Y, Jeong D. Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. Nature Communications 2021, 12: 2258. PMID: 33859201, PMCID: PMC8050258, DOI: 10.1038/s41467-021-22565-7.Peer-Reviewed Original ResearchConceptsSelenoprotein WCell-cell fusionRNA sequencing analysisProfile of receptor activationOsteoclast differentiationNuclear factor of activated T cells cytoplasmic 1Bone remodelingBone mass phenotypeOsteoclastogenesis in vitroNuclear translocation of NF-kBTranslocation of NF-kBPhysiological bone remodelingBlocks osteoporosisNuclear translocationNuclear factorOsteoclastogenic genesMechanism of actionMass phenotypeBone metabolismBone resorptionReceptor activationOsteoclast maturationCytoplasmic 1Osteoclast formationNF-kB
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