Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice
Kim H, Shim Y, Choi S, Falana T, Yoo J, Ahn S, Park M, Seo H, Choi C, Jeong W. Exosome-Based Delivery of Super-Repressor IκBα Alleviates Alcohol-Associated Liver Injury in Mice. Pharmaceutics 2023, 15: 636. PMID: 36839957, PMCID: PMC9965399, DOI: 10.3390/pharmaceutics15020636.Peer-Reviewed Original ResearchAlcohol-associated liver injuryAlcohol-associated liver diseaseInflammatory gene expression levelsInfiltration of neutrophilsKupffer cellsLiver injuryModulation of NF-kB activationActivation of Kupffer cellsGene expression levelsExpression levelsAlcohol binge drinkingNuclear translocation of NF-kBGut-derived lipopolysaccharideHepatic stellate cellsTranslocation of NF-kBNuclear factor-KBNF-kB activationEfficient therapeutic approachApoptosis of hepatocytesIntravenous injectionLiver diseaseTherapeutic approachesExosome technologyInflammatory responseStellate cells
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