2019
Signal peptide peptidase‐like 2c impairs vesicular transport and cleaves SNARE proteins
Papadopoulou A, Müller S, Mentrup T, Shmueli M, Niemeyer J, Haug‐Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler S, Fluhrer R. Signal peptide peptidase‐like 2c impairs vesicular transport and cleaves SNARE proteins. EMBO Reports 2019, 20: embr201846451. PMID: 30733281, PMCID: PMC6399617, DOI: 10.15252/embr.201846451.Peer-Reviewed Original ResearchMeSH KeywordsAcrosomeAnimalsAspartic Acid EndopeptidasesBiocatalysisDown-RegulationGlycomicsGlycoproteinsGlycosyltransferasesGolgi ApparatusHEK293 CellsHumansMaleMembrane ProteinsMice, Inbred C57BLModels, BiologicalProtein TransportProteolysisSNARE ProteinsSpermatidsSubcellular FractionsSubstrate SpecificityConceptsSNARE proteinsCandidate substratesVesicular transportProcess of vesicular traffickingImpaired vesicular transportIntramembrane aspartyl proteaseCleave SNARE proteinsGxGD-typeAcrosome formationB cell developmentCargo proteinsVesicular traffickingAspartyl proteaseProtease familyCellular processesProtein glycosylationSubcellular compartmentsEndoplasmic reticulumProteolytic processingBiological processesAlzheimer's diseasePhysiological functionsProteinDevelopment of pathologyProtease
2011
The crystal structure of GXGD membrane protease FlaK
Hu J, Xue Y, Lee S, Ha Y. The crystal structure of GXGD membrane protease FlaK. Nature 2011, 475: 528-531. PMID: 21765428, PMCID: PMC3894692, DOI: 10.1038/nature10218.Peer-Reviewed Original ResearchConceptsFamily of proteasesFirst crystal structureIntramembrane proteasesPrepilin peptidaseMethanococcus maripaludisMembrane proteasePreflagellin peptidaseFamilial Alzheimer's diseaseVirulence factorsAspartyl proteaseBiochemical analysisProteasePathogenic bacteriaStructural knowledgePresenilinPeptidaseCrystal structureSoluble counterpartActive siteFamilyRational designAspartylBacteriaAlzheimer's diseaseFundamental differences
2002
Synthesis and Characterization of the First Potent Inhibitor of Yapsin 1 IMPLICATIONS FOR THE STUDY OF YAPSIN-LIKE ENZYMES*
Cawley NX, Chino M, Maldonado A, Rodriguez YM, Loh YP, Ellman JA. Synthesis and Characterization of the First Potent Inhibitor of Yapsin 1 IMPLICATIONS FOR THE STUDY OF YAPSIN-LIKE ENZYMES*. Journal Of Biological Chemistry 2002, 278: 5523-5530. PMID: 12468548, DOI: 10.1074/jbc.m207230200.Peer-Reviewed Original ResearchConceptsYapsin 1Aspartyl proteaseN-terminal amino acid sequence analysisYeast expression systemAmino acid sequence analysisSecreted aspartyl proteaseAcid sequence analysisPotent peptidic inhibitorsSingle-step purificationBasic residuesExpression systemSequence analysisApparent homogeneityPeptidic inhibitorsHuman pathogensPeptide sequencesNonmammalian sourcesFirst potent inhibitorPotent inhibitorProteaseEnzymeCandida albicansSequenceInhibitorsPurification
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