2007
Cannabinoids Excite Hypothalamic Melanin-Concentrating Hormone But Inhibit Hypocretin/Orexin Neurons: Implications for Cannabinoid Actions on Food Intake and Cognitive Arousal
Huang H, Acuna-Goycolea C, Li Y, Cheng HM, Obrietan K, van den Pol AN. Cannabinoids Excite Hypothalamic Melanin-Concentrating Hormone But Inhibit Hypocretin/Orexin Neurons: Implications for Cannabinoid Actions on Food Intake and Cognitive Arousal. Journal Of Neuroscience 2007, 27: 4870-4881. PMID: 17475795, PMCID: PMC6672093, DOI: 10.1523/jneurosci.0732-07.2007.Peer-Reviewed Original ResearchConceptsMelanin-concentrating hormoneHypocretin neuronsMCH cellsCannabinoid actionGreen fluorescent protein-expressing transgenic miceSpike frequencyIonotropic glutamate receptor antagonistsHypocretin/orexin neuronsLocal inhibitory cellsReceptor agonist RSynaptic GABA releaseReceptor antagonist bicucullineGlutamate receptor antagonistsPatch-clamp recordingsGlutamatergic currentsNaphthalenylmethanone mesylatePresynaptic attenuationMiniature IPSCsMCH neuronsAgonist RAntagonist bicucullineGABA releaseOrexin neuronsPostsynaptic effectsSpontaneous IPSCs
2006
GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical Malformation
Trotter S, Kapur J, Anzivino M, Lee K. GABAergic Synaptic Inhibition Is Reduced before Seizure Onset in a Genetic Model of Cortical Malformation. Journal Of Neuroscience 2006, 26: 10756-10767. PMID: 17050714, PMCID: PMC6674751, DOI: 10.1523/jneurosci.2323-06.2006.Peer-Reviewed Original ResearchConceptsSpontaneous IPSCsSeizure onsetCortical malformationsPyramidal neuronsAmplitude of spontaneous IPSCsFrequency of spontaneous IPSCsCalcium-binding protein parvalbuminGABAergic synaptic inhibitionHeightened seizure susceptibilityInhibitory GABAergic neurotransmissionPresynaptic GABAergic terminalsGABAergic synaptic transmissionResting membrane potentialPyramidal cell somataHigher input resistanceTish cortexMiniature IPSCsNeocortical malformationsSynaptic inhibitionGABAergic interneuronsGABAergic neurotransmissionSeizure susceptibilityProtein parvalbuminImmunohistochemical assessmentGABAergic terminals
2004
Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons
Huang H, Bordey A. Glial Glutamate Transporters Limit Spillover Activation of Presynaptic NMDA Receptors and Influence Synaptic Inhibition of Purkinje Neurons. Journal Of Neuroscience 2004, 24: 5659-5669. PMID: 15215288, PMCID: PMC6729224, DOI: 10.1523/jneurosci.1338-04.2004.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino Acid Transport System X-AGAnimalsAntiportersCalciumCerebellumCystineEvoked Potentialsgamma-Aminobutyric AcidGlutamic AcidIn Vitro TechniquesMiceNerve FibersNeural InhibitionNeurogliaPatch-Clamp TechniquesPurkinje CellsReceptors, N-Methyl-D-AspartateReceptors, PresynapticRyanodineSynaptic TransmissionConceptsGlial glutamate transportersMiniature IPSCsPurkinje neuronsGlutamate transportersSpontaneous IPSCsSynaptic inhibitionInhibitory synapsesNMDAR activationWhole-cell patch-clamp recordingsPresynaptic NMDA receptorsPaired-pulse ratioMouse cerebellar slicesNMDA receptor activationPresynaptic NMDA receptor activationPatch-clamp recordingsBergmann glial cellsBeta-benzyloxyaspartic acidAdjacent Purkinje neuronsCystine-glutamate antiporterMIPSC frequencyGABAergic terminalsGABAergic synapsesGlial cellsNMDA receptorsExcitatory synapses
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