Catalyst-Controlled Site-Selective and Epimer-Selective Hydrogenations of Thiostrepton
Peterson P, Mercado B, Miller S. Catalyst-Controlled Site-Selective and Epimer-Selective Hydrogenations of Thiostrepton. Journal Of The American Chemical Society 2025, 147: 17161-17169. PMID: 40358225, PMCID: PMC12126753, DOI: 10.1021/jacs.5c02720.Peer-Reviewed Original ResearchConceptsPhosphoramidite ligandAsymmetric hydrogenation methodMonodentate phosphoramidite ligandsStereoselectivity of reductionX-ray crystallographyStudies of ligandsModel substrateProtecting-groupLigand chiralityLigand scaffoldStereochemical outcomeAbsolute stereochemistryMild conditionsMultidimensional nuclear magnetic resonance methodsNuclear magnetic resonance methodsDehydroalanine residueHydrogenation methodLigandX-rayHydrogenStereoisomersStereochemistryControlled formationStericallyMagnetic resonance methods
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