2021
Mitochondrial translation is required for sustained killing by cytotoxic T cells
Lisci M, Barton P, Randzavola L, Ma C, Marchingo J, Cantrell D, Paupe V, Prudent J, Stinchcombe J, Griffiths G. Mitochondrial translation is required for sustained killing by cytotoxic T cells. Science 2021, 374: eabe9977. PMID: 34648346, DOI: 10.1126/science.abe9977.Peer-Reviewed Original ResearchConceptsCytotoxic T lymphocytesMitochondrial translationSustained killingT lymphocytesEffector cytotoxic T lymphocytesAcquisition of effector functionsCD8<sup>+</sup> T lymphocytesCytotoxic T lymphocyte killingCytotoxic T cellsT cell receptor activationImpaired mitochondrial translationRegulation of protein translationVirally infected cellsTarget cell-killingCTL killingT cellsMitochondrial requirementsCytosolic translationEffector functionsProtein translationCell-killingKill cancerKilling capacityMitochondrial depletionHomeostatic regulation
2017
Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome
Lake N, Webb B, Stroud D, Richman T, Ruzzenente B, Compton A, Mountford H, Pulman J, Zangarelli C, Rio M, Boddaert N, Assouline Z, Sherpa M, Schadt E, Houten S, Byrnes J, McCormick E, Zolkipli-Cunningham Z, Haude K, Zhang Z, Retterer K, Bai R, Calvo S, Mootha V, Christodoulou J, Rötig A, Filipovska A, Cristian I, Falk M, Metodiev M, Thorburn D. Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome. American Journal Of Human Genetics 2017, 101: 239-254. PMID: 28777931, PMCID: PMC5544391, DOI: 10.1016/j.ajhg.2017.07.005.Peer-Reviewed Original ResearchConceptsSmall mitoribosomal subunitMitoribosomal subunitHuman oxidative phosphorylation (OXPHOS) systemMitochondrial protein translationOxidative phosphorylation systemMitochondrial translation defectQuantitative proteomic analysisSpecific cellular pathwaysLeigh syndromeLentiviral-mediated expressionMitoribosomal proteinsMitochondrial ribosomesOXPHOS subunitsMitochondrial translationOXPHOS defectsProtein translationMitochondrial DNATranslation defectsUnrelated familiesProteomic analysisPhosphorylation systemQuantitative proteomicsCellular pathwaysProtein subunitsSubunit proteins
2006
Saccharomyces cerevisiae imports the cytosolic pathway for Gln‐tRNA synthesis into the mitochondrion
Krett B, Rinehart J, Rubio M, Alfonzo J, Söll D. Saccharomyces cerevisiae imports the cytosolic pathway for Gln‐tRNA synthesis into the mitochondrion. The FASEB Journal 2006, 20: a500-a500. DOI: 10.1096/fasebj.20.4.a500-b.Peer-Reviewed Original ResearchTransamidation pathwayMitochondrial translationGln-tRNAOrganellar protein synthesisYeast mitochondrial DNAGlutaminyl-tRNA synthetaseAminoacyl-tRNA synthetasesAminoacyl-tRNA formationImport mechanismMitochondrial localizationMitochondrial DNAProtein biosynthesisMost bacteriaCytoplasmic componentsAlternate functionsCytosolic pathwayProtein synthesisAmino acidsEssential processMitochondriaTRNAPathwayEukaryotesGlnRArchaea
1997
A nuclear genetic lesion affecting Saccharomyces cerevisiae mitochondrial translation is complemented by a homologous Bacillus gene
Kim S, Stange-Thomann N, Martins O, Hong K, Söll D, Fox T. A nuclear genetic lesion affecting Saccharomyces cerevisiae mitochondrial translation is complemented by a homologous Bacillus gene. Journal Of Bacteriology 1997, 179: 5625-5627. PMID: 9287027, PMCID: PMC179443, DOI: 10.1128/jb.179.17.5625-5627.1997.Peer-Reviewed Original ResearchMeSH KeywordsBacillus subtilisDNA, FungalDNA, MitochondrialFungal ProteinsGenes, BacterialMitochondrial ProteinsMolecular Sequence DataProtein BiosynthesisRecombinant Fusion ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Analysis, DNASequence Homology, Amino AcidTransaminasesTranscription Factors
1996
[4] In Organello mitochondrial protein and RNA synthesis systems from Saccharomyces cereuisiae
Poyton R, Bellus G, McKee E, Sevarino K, Goehring B. [4] In Organello mitochondrial protein and RNA synthesis systems from Saccharomyces cereuisiae. Methods In Enzymology 1996, 264: 36-42. PMID: 8965710, DOI: 10.1016/s0076-6879(96)64006-3.Peer-Reviewed Original ResearchConceptsMitochondrial translation productsTranslation productsMitochondrial gene productsRNase P enzymesMitochondrial gene expressionInner mitochondrial membraneOrganello systemMitochondrial genomeMitochondrial transcriptionMitochondrial translationP enzymesTRNA processingMitochondrial proteinsRNA splicingSmall rRNAProteolytic turnoverRNA synthesis systemRNA componentRespiratory proteinsGene productsMitochondrial membraneTranscription systemGene expressionPolypeptide subunitsRNA synthesis
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