Mitochondrial translation is required for sustained killing by cytotoxic T cells
Lisci M, Barton P, Randzavola L, Ma C, Marchingo J, Cantrell D, Paupe V, Prudent J, Stinchcombe J, Griffiths G. Mitochondrial translation is required for sustained killing by cytotoxic T cells. Science 2021, 374: eabe9977. PMID: 34648346, DOI: 10.1126/science.abe9977.Peer-Reviewed Original ResearchConceptsCytotoxic T lymphocytesMitochondrial translationSustained killingT lymphocytesEffector cytotoxic T lymphocytesAcquisition of effector functionsCD8<sup>+</sup> T lymphocytesCytotoxic T lymphocyte killingCytotoxic T cellsT cell receptor activationImpaired mitochondrial translationRegulation of protein translationVirally infected cellsTarget cell-killingCTL killingT cellsMitochondrial requirementsCytosolic translationEffector functionsProtein translationCell-killingKill cancerKilling capacityMitochondrial depletionHomeostatic regulation
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