Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma
Lee L, Cavalcanti M, Segal N, Hechtman J, Weiser M, Smith J, Garcia-Aguilar J, Sadot E, Ntiamoah P, Markowitz A, Shike M, Stadler Z, Vakiani E, Klimstra D, Shia J. Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma. Modern Pathology 2016, 29: 1433-1442. PMID: 27443512, PMCID: PMC5083129, DOI: 10.1038/modpathol.2016.139.Peer-Reviewed Original ResearchConceptsProgrammed death-ligand 1PD-1-positive tumor-infiltrating lymphocytesProgrammed death-ligand 1 expressionTumor-infiltrating lymphocytesProgrammed death-1Mismatch repair-deficient colorectal carcinomasRecurrence-free survivalAnti-PD-1 therapyPD-L1 expressionColorectal carcinomaMismatch repair-deficient tumorsPredictive markerPrognostic impact of tumor-infiltrating lymphocytesResponse to anti-PD-1 therapyHigh programmed death ligand-1Impact of tumor-infiltrating lymphocytesProgrammed death ligand 1 levelPD-1 levelsTumor PD-L1 expressionProgrammed death-1 expressionAssociated with better prognosisMismatch repair-proficient tumorsImmune checkpoint blockadePD-1 expressionPD-L1 immunohistochemistry
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