2024
Measuring clinically relevant change in apathy symptoms in ADMET and ADMET 2
Tumati S, Herrmann N, Perin J, Rosenberg P, Lerner A, Mintzer J, Padala P, Brawman-Mintzer O, van Dyck C, Porsteinsson A, Craft S, Levey A, Shade D, Lanctôt K. Measuring clinically relevant change in apathy symptoms in ADMET and ADMET 2. International Psychogeriatrics 2024, 36: 1232-1244. PMID: 39297292, PMCID: PMC11695175, DOI: 10.1017/s1041610224000711.Peer-Reviewed Original ResearchDementia Apathy Interview and RatingMinimal Clinically Important DifferenceDistribution-based analysisMeasure clinically relevant changesClinically Important DifferenceClinically significant apathyAnchor-based analysesDementia careGlobal Impression of ChangeImpression of ChangeLinear mixed modelsAlzheimer's diseaseClinically relevant changesMMSE scoreImportant differenceApathy symptomsApathy ScaleControlled TrialsSignificant apathyAnchor measuresDementiaStudy visitsApathy severityMethylphenidate trialSymptom severityFeedback System Analysis of a Multicomponent Intervention on Dyads of Home-Dwelling Persons With Dementia and Their Caregivers: Results From the LIVE@Home.Path Trial
Vislapuu M, Patrascu M, Allore H, Husebo B, Kjerstad E, Gedde M, Berge L. Feedback System Analysis of a Multicomponent Intervention on Dyads of Home-Dwelling Persons With Dementia and Their Caregivers: Results From the LIVE@Home.Path Trial. Innovation In Aging 2024, 8: igae020. PMID: 38550899, PMCID: PMC10976912, DOI: 10.1093/geroni/igae020.Peer-Reviewed Original ResearchInformal care timeCare timeInformal caregiversCaregiving experienceMulticomponent interventionStepped-wedge randomized controlled trialMild to moderate dementiaDementia Care CoordinationHome-dwelling personsInformal caregivers' experiencesInformal caregiver supportComplex intervention studiesDementia careRandomized Controlled TrialsCare coordinationCaregiving situationCaregiver supportSymptom managementGlobal Impression of ChangeClinical Global Impression of ChangeCare situationsModerate dementiaHealth servicesCare burdenImpression of Change
2023
P105: Measuring clinically relevant change in apathy symptoms in ADMET 2
Tuma S, Herrmann N, Perin J, Rosenberg P, Lerner A, Padala P, Brawman-Mintzer O, van Dyck C, Porsteinsson A, CraG S, Levey A, Shade D, Mintzer J, Lanctôt K. P105: Measuring clinically relevant change in apathy symptoms in ADMET 2. International Psychogeriatrics 2023, 35: 126-127. DOI: 10.1017/s1041610223002569.Peer-Reviewed Original ResearchImpression of ChangeChange scoresMeasure clinically relevant changesNPI apathy scoreEffect sizeClinical impression of changeMinimal clinically significant improvementClinical Global Impression of ChangeSpearman correlationClinical Global ImpressionClinically significant improvementSix-month visitGlobal Impression of ChangePsychosocial interventionsClinically relevant changesApathy symptomsAssessment ScaleAssessment Change ScoreMann-Whitney U testComplete dataWorsened groupParticipantsApathyNo changeTreatment trials
2021
Validation of the Radiographic Global Impression of Change (RGI-C) score to assess healing of rickets in pediatric X-linked hypophosphatemia (XLH)
Lim R, Shailam R, Hulett R, Skrinar A, Nixon A, Williams A, Nixon M, Thacher T. Validation of the Radiographic Global Impression of Change (RGI-C) score to assess healing of rickets in pediatric X-linked hypophosphatemia (XLH). Bone 2021, 148: 115964. PMID: 33878504, DOI: 10.1016/j.bone.2021.115964.Peer-Reviewed Original ResearchConceptsRickets Severity ScaleInter-rater reliabilityGlobal Impression of ChangeX-linked hypophosphatemiaIntra-raterImpression of ChangeRadiographic Global Impression of ChangeGlobal scoreRGI-CModerate to almost perfect agreementStandardized response meanIntra-rater reliabilityAlmost perfect agreementWeighted kappa valuesResponse meanChange scoresStanding heightBaseline to weekLeg scoreHealing of ricketsSeverity ScalePerfect agreementRickets severityBurosumab treatmentKappa values
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