1996
Microbial killing by human neutrophil cytokineplasts: similar suppressive effects of reversible and irreversible inhibitors of nitric oxide synthase
Malawista S, Montgomery R, van Blaricom G. Microbial killing by human neutrophil cytokineplasts: similar suppressive effects of reversible and irreversible inhibitors of nitric oxide synthase. Journal Of Leukocyte Biology 1996, 60: 753-757. PMID: 8975878, DOI: 10.1002/jlb.60.6.753.Peer-Reviewed Original ResearchConceptsNO synthase inhibitorSynthase inhibitorL-NIOMin of incubationMonomethyl-L-arginineNitric oxide synthaseHuman blood neutrophilsSimilar suppressive effectReactive nitrogen intermediatesL-Arg analoguesIrreversible inhibitorBlood neutrophilsOxide synthaseSuppressive effectKilling capacityL-arginineKilling pathwaysHuman neutrophilsL-ArgD-ArgNeutrophilsNitrogen intermediatesMicrobial killingGranule contentsIntact neutrophils
1994
Inhibition of protein kinase C of human neutrophils by phosphatidylcholines
Yoshida K, Mohsenin V. Inhibition of protein kinase C of human neutrophils by phosphatidylcholines. Life Sciences 1994, 54: 515-524. PMID: 8107528, DOI: 10.1016/0024-3205(94)90001-9.Peer-Reviewed Original ResearchConceptsEffect of phosphatidylcholineProtein kinase CActivation of neutrophilsIntact neutrophilsMechanism of actionPKC activityPulmonary surfactant phospholipidsNeutrophil activationActivation of PKCKinase CNeutrophilsIntact restingTranslocation of PKCHuman neutrophilsSurfactant phospholipidsCytosolic PKC activityDistribution of PKCSuperoxide generationControl cellsPulmonary surfactantSpecific phosphatidylcholinesStimulationActivationFatty acyl moietiesInhibition
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