2025
Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex
Hauptman J, Antonios J, Mathern G, Levine M, Cepeda C. Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex. Cells 2025, 14: 79. PMID: 39851507, PMCID: PMC11764219, DOI: 10.3390/cells14020079.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronsMice treated with rapamycinGABA releasePTEN deletionWhole-cell patch-clamp recordingsMiniature inhibitory postsynaptic currentsEx vivo slicesNeuronal somatic sizeReduced neuronal firingInhibitory postsynaptic currentsChronic rapamycin treatmentPatch-clamp recordingsIncreased input resistanceInhibitory synaptic inputsDevelopmental brain disordersRapamycin treatmentIncreased membrane capacitanceConditional mouse modelChronic treatmentPostsynaptic currentsClamp recordingsNaive miceSynaptic excitationBrain disordersControl mice
2011
mTOR Controls Ovarian Follicle Growth by Regulating Granulosa Cell Proliferation
Yu J, Yaba A, Kasiman C, Thomson T, Johnson J. mTOR Controls Ovarian Follicle Growth by Regulating Granulosa Cell Proliferation. PLOS ONE 2011, 6: e21415. PMID: 21750711, PMCID: PMC3130037, DOI: 10.1371/journal.pone.0021415.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsApoptosisBlotting, WesternCarrier ProteinsCell DivisionCell Line, TransformedCell ProliferationDose-Response Relationship, DrugFemaleFlow CytometryG1 PhaseGranulosa CellsImmunosuppressive AgentsMaleMiceMice, Inbred C57BLOvarian FolliclePhosphorylationRatsRegulatory-Associated Protein of mTORRibosomal Protein S6 Kinases, 70-kDaSirolimusTOR Serine-Threonine KinasesConceptsAberrant mitotic figuresGranulosa cellsFollicle growthMitotic figuresMice treated with rapamycinFraction of granulosa cellsEffects of mTOR inhibitionRegulation of follicle growthDose-dependent increaseDose-dependent reductionRegulating granulosa cell proliferationGranulosa cell proliferationReduced compared to controlsMTOR pathway activationAberrant mitotic eventsExpression of RaptorOvarian follicle growthOvarian folliclesInhibition of mTORPresence of rapamycinMTOR inhibitionGranulosaInhibitor rapamycinConsequences of increased numbersMitotic index
2004
Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer
Boffa D, Luan F, Thomas D, Yang H, Sharma V, Lagman M, Suthanthiran M. Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer. Clinical Cancer Research 2004, 10: 293-300. PMID: 14734482, DOI: 10.1158/1078-0432.ccr-0629-3.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerMice treated with cyclosporineMice treated with rapamycinCell lung cancerProgression of non-small cell lung cancerMetastatic progressionEffects of rapamycinLung cancerIn vitro effectsKLN-205Pulmonary metastasesDBA/2 miceTumor growthIn vitro effects of cyclosporineFormation of distant metastasesNSCLC cellsSyngeneic DBA/2 miceUntreated DBA/2 miceRecipients of allograftsPost-transplant malignanciesCell cycle progressionA-549 cellsEffect of cyclosporineImmunosuppressive macrolide rapamycinInduced cell cycle arrest
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