2025
Meningeal lymphatics-microglia axis regulates synaptic physiology
Kim K, Abramishvili D, Du S, Papadopoulos Z, Cao J, Herz J, Smirnov I, Thomas J, Colonna M, Kipnis J. Meningeal lymphatics-microglia axis regulates synaptic physiology. Cell 2025, 188: 2705-2719.e23. PMID: 40120575, PMCID: PMC12086007, DOI: 10.1016/j.cell.2025.02.022.Peer-Reviewed Original ResearchConceptsBehavioral alterationsAging-associated cognitive declineMemory taskNeural mechanismsIL-6Cognitive declineIL-6-dependent mechanismInhibitory synaptic inputsCortical circuitryBehavioral changesMeningeal lymphaticsInterleukin-6 geneIL-6 signalingAge-associatedSynaptic inputsLymphatic dysfunctionLymphatic functionCerebrospinal fluidProlonged impairmentIncreased expressionNeurodegenerative conditionsLymphaticsPotential targetDysfunctionDeficitsChronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex
Hauptman J, Antonios J, Mathern G, Levine M, Cepeda C. Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex. Cells 2025, 14: 79. PMID: 39851507, PMCID: PMC11764219, DOI: 10.3390/cells14020079.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronsMice treated with rapamycinGABA releasePTEN deletionWhole-cell patch-clamp recordingsMiniature inhibitory postsynaptic currentsEx vivo slicesNeuronal somatic sizeReduced neuronal firingInhibitory postsynaptic currentsChronic rapamycin treatmentPatch-clamp recordingsIncreased input resistanceInhibitory synaptic inputsDevelopmental brain disordersRapamycin treatmentIncreased membrane capacitanceConditional mouse modelChronic treatmentPostsynaptic currentsClamp recordingsNaive miceSynaptic excitationBrain disordersControl mice
1988
New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain
Waterhouse B, Sessler F, Jung-Tung C, Woodward D, Azizi S, Moises H. New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain. Brain Research Bulletin 1988, 21: 425-432. PMID: 3214748, DOI: 10.1016/0361-9230(88)90154-2.Peer-Reviewed Original ResearchConceptsSynaptic inputsNeuronal responses to synaptic inputsResponse to synaptic inputsInhibitory synaptic inputsCentral neuronal circuitsMammalian brainEffects of norepinephrineAction of norepinephrineTissue slice preparationSingle unit recordingsSlice preparationSynaptic stimuliLocus coeruleusCentral neuronsSpontaneous dischargeModulatory actionBehavioral conditionsSynaptic releaseNorepinephrineDepressant actionUnit recordingsNeuronal responsesPathway stimulationBrainTransmitter substances
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