2022
Functional Analysis of MET Exon 14 Skipping Alteration in Cancer Invasion and Metastatic DisseminationMET Exon 14 Skipping Alteration Promotes Metastasis
Wang F, Liu Y, Qiu W, Shum E, Feng M, Zhao D, Zheng D, Borczuk A, Cheng H, Halmos B. Functional Analysis of MET Exon 14 Skipping Alteration in Cancer Invasion and Metastatic DisseminationMET Exon 14 Skipping Alteration Promotes Metastasis. Cancer Research 2022, 82: 1365-1379. PMID: 35078819, DOI: 10.1158/0008-5472.can-21-1327.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerMetastasis in vivoLung cancerInvasive capacity in vitroExtracellular matrix disassemblyReceptor kinase activityTumor progression of non-small cell lung cancerRNA sequencing analysisImpaired receptor internalizationTreatment of lung cancerMetastasis-related pathwaysCell lung cancerMolecular mechanisms of actionCytoskeleton remodelingEndocytic degradationSequence analysisCell scatteringEffective treatment of lung cancerPotential therapeutic optionCRISPR editingCell movementKinase activityMechanistic functionProgression of non-small cell lung cancerMatrix disassembly
2004
Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer
Boffa D, Luan F, Thomas D, Yang H, Sharma V, Lagman M, Suthanthiran M. Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer. Clinical Cancer Research 2004, 10: 293-300. PMID: 14734482, DOI: 10.1158/1078-0432.ccr-0629-3.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerMice treated with cyclosporineMice treated with rapamycinCell lung cancerProgression of non-small cell lung cancerMetastatic progressionEffects of rapamycinLung cancerIn vitro effectsKLN-205Pulmonary metastasesDBA/2 miceTumor growthIn vitro effects of cyclosporineFormation of distant metastasesNSCLC cellsSyngeneic DBA/2 miceUntreated DBA/2 miceRecipients of allograftsPost-transplant malignanciesCell cycle progressionA-549 cellsEffect of cyclosporineImmunosuppressive macrolide rapamycinInduced cell cycle arrest
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