2024
Abstract 1147: Crosstalk Between Alk5 And Mtorc1 Signaling Promotes VSMC Differentiation And The Therapeutic Effect Of Rapamycin
Chakraborty R, Chatterjee P, Dave J, Obrien B, Joshi D, Schulz V, Greif D, Hwa J, Gallagher P, Martin K. Abstract 1147: Crosstalk Between Alk5 And Mtorc1 Signaling Promotes VSMC Differentiation And The Therapeutic Effect Of Rapamycin. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: a1147-a1147. DOI: 10.1161/atvb.44.suppl_1.1147.Peer-Reviewed Original ResearchVascular smooth muscle cellsTherapeutic effect of rapamycinEffects of rapamycinVSMC differentiationContractile genesConsistent with in vitro findingsRapamycin treatmentCarotid artery injuryHuman coronary artery SMCsVascular smooth muscle cell differentiationIntimal hyperplasiaSmooth muscle cellsCoronary artery SMCsMTORC1 inhibitor rapamycinPhosphorylation of Smad2/3Inhibition of ALK5Smad-binding elementSmad transcription factorsALK5 activityArterial injuryArtery SMCsKnockout miceInhibition of mTORC1Vascular Smooth Muscle Cell PlasticityMuscle cells
2004
Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer
Boffa D, Luan F, Thomas D, Yang H, Sharma V, Lagman M, Suthanthiran M. Rapamycin Inhibits the Growth and Metastatic Progression of Non-Small Cell Lung Cancer. Clinical Cancer Research 2004, 10: 293-300. PMID: 14734482, DOI: 10.1158/1078-0432.ccr-0629-3.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerMice treated with cyclosporineMice treated with rapamycinCell lung cancerProgression of non-small cell lung cancerMetastatic progressionEffects of rapamycinLung cancerIn vitro effectsKLN-205Pulmonary metastasesDBA/2 miceTumor growthIn vitro effects of cyclosporineFormation of distant metastasesNSCLC cellsSyngeneic DBA/2 miceUntreated DBA/2 miceRecipients of allograftsPost-transplant malignanciesCell cycle progressionA-549 cellsEffect of cyclosporineImmunosuppressive macrolide rapamycinInduced cell cycle arrest
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