2025
Enhancing prognostic accuracy in lung cancer brain metastases through histopathologic feature integration and AI-based image analysis.
Breuer G, Sritharan D, Chadha S, Hager T, Fu D, Aneja S. Enhancing prognostic accuracy in lung cancer brain metastases through histopathologic feature integration and AI-based image analysis. Journal Of Clinical Oncology 2025, 43: e13608-e13608. DOI: 10.1200/jco.2025.43.16_suppl.e13608.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesCox proportional hazards modelsClinical featuresHistopathological featuresProportional hazards modelLung adenocarcinoma metastasisWhole slide imagesBrain metastasesAdenocarcinoma metastasisManagement of brain metastasesLung cancer brain metastasisBrain metastasis diagnosisCancer brain metastasesHazards modelEstimate overall survivalSystemic disease controlOverall survival estimatesGround-truth labelsAttention-based modelAttention-based networkMetastasis biopsiesSlide imagesNeural network-based modelOverall survivalAI-based image analysis
2023
A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells.
Calvo V, Zheng W, Adam-Artigues A, Staschke K, Huang X, Cheung J, Nobre A, Fujisawa S, Liu D, Fumagalli M, Surguladze D, Stokes M, Nowacek A, Mulvihill M, Farias E, Aguirre-Ghiso J. A PERK-Specific Inhibitor Blocks Metastatic Progression by Limiting Integrated Stress Response-Dependent Survival of Quiescent Cancer Cells. Clinical Cancer Research 2023, 29: 5155-5172. PMID: 37982738, PMCID: PMC10842363, DOI: 10.1158/1078-0432.ccr-23-1427.Peer-Reviewed Original ResearchCancer cellsIntegrated stress responsePERK inhibitionRounds of therapyPERK inhibitorDormant cancer cellsQuiescent cancer cellsMicro-metastatic lesionsAnti-proliferative therapiesMetastasis biopsiesMetastatic burdenCDK4/6 inhibitorsPDX modelsSingle-cell gene expression profilingHER2 activityMetastatic progressionGene expression profilingSurvival factorUnresolved ER stressHigh expressionMouse syngeneicER stressMetastasisHER2Therapy
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