2025
Enhancing prognostic accuracy in lung cancer brain metastases through histopathologic feature integration and AI-based image analysis.
Breuer G, Sritharan D, Chadha S, Hager T, Fu D, Aneja S. Enhancing prognostic accuracy in lung cancer brain metastases through histopathologic feature integration and AI-based image analysis. Journal Of Clinical Oncology 2025, 43: e13608-e13608. DOI: 10.1200/jco.2025.43.16_suppl.e13608.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesCox proportional hazards modelsClinical featuresHistopathological featuresProportional hazards modelLung adenocarcinoma metastasisWhole slide imagesBrain metastasesAdenocarcinoma metastasisManagement of brain metastasesLung cancer brain metastasisBrain metastasis diagnosisCancer brain metastasesHazards modelEstimate overall survivalSystemic disease controlOverall survival estimatesGround-truth labelsAttention-based modelAttention-based networkMetastasis biopsiesSlide imagesNeural network-based modelOverall survivalAI-based image analysis
2024
HLA class-I antigen presentation machinery (APM) alterations mediate immune evasion in lung cancer brain metastases.
Vilariño N, Lopez De Rodas M, Ranjan K, Costantini A, Villalba M, Lu B, Kravitz C, Nadal E, Goldberg S, Nguyen D, Schalper K. HLA class-I antigen presentation machinery (APM) alterations mediate immune evasion in lung cancer brain metastases. Journal Of Clinical Oncology 2024, 42: e14014-e14014. DOI: 10.1200/jco.2024.42.16_suppl.e14014.Peer-Reviewed Original ResearchLung cancer brain metastasisPrimary lung tumorsTumor-infiltrating lymphocytesImmune checkpoint inhibitorsCancer brain metastasesAntigen presentation machineryB2M expressionIFN-gBrain metastasesB2MImmune evasionAssociated with shorter overall survivalMultiplexed quantitative immunofluorescenceM expressionExpression of B2MB2M levelsExpression of pSTAT1Shorter overall survivalUnfavorable clinical featuresNo significant associationAssociated with unfavorable clinical featuresCheckpoint inhibitorsImmunotherapy resistanceProperties of tumorsPresentation machinery
2021
Abstract PO-041: An immunologic niche of antigen presenting cells and stem-like CD8+ T-cells is present in non-small cell lung cancer brain metastases
Jansen C, del Balzo L, Prabhu R, Logan S, Chappa P, Patel K, Wilkinson S, Lake R, Shu H, Zhong J, Dhere V, Olson J, Sowalsky A, Khan M, Kissick H, Buchwald Z. Abstract PO-041: An immunologic niche of antigen presenting cells and stem-like CD8+ T-cells is present in non-small cell lung cancer brain metastases. Clinical Cancer Research 2021, 27: po-041-po-041. DOI: 10.1158/1557-3265.radsci21-po-041.Peer-Reviewed Original ResearchCD8+ T cellsStem-like CD8+ T cellsNon-small cell lung cancer brain metastasisNon-small cell lung cancerAntigen presenting cellsLung cancer brain metastasisStereotactic radiosurgeryBrain metastasesCancer brain metastasesImmune nicheT cellsPresenting cellsMHC-II+TCF-1CD8+ T cell infiltrationImmunological nichePost-operative stereotactic radiosurgeryPre-operative stereotactic radiosurgeryT cell infiltrationCell lung cancerCohort of patientsCheckpoint blockadePD-1Disease recurrenceGenitourinary malignancies
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