2024
Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity
Leon S, Simon V, Lee T, Steuernagel L, Clark S, Biglari N, Lesté-Lasserre T, Dupuy N, Cannich A, Bellocchio L, Zizzari P, Allard C, Gonzales D, Le Feuvre Y, Lhuillier E, Brochard A, Nicolas J, Teillon J, Nikolski M, Marsicano G, Fioramonti X, Brüning J, Cota D, Quarta C. Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity. Nature Communications 2024, 15: 3443. PMID: 38658557, PMCID: PMC11043070, DOI: 10.1038/s41467-024-47877-2.Peer-Reviewed Original ResearchConceptsPOMC neuronsMouse models of obesityHypothalamic pro-opiomelanocortinAdult male miceDiet-induced obese miceModels of obesityReporter micePOMC expressionHypothalamic functionMale miceMature hypothalamusMouse modelDiversity of neuronsNeuronal diversityNeuronal identityObese micePro-opiomelanocortinSingle cell tracingNeuron numberPOMCMiceLineage tracingNeuronsWeight lossMetabolic output
2023
Cross-feeding in the gut microbiome: Ecology and mechanisms
Culp E, Goodman A. Cross-feeding in the gut microbiome: Ecology and mechanisms. Cell Host & Microbe 2023, 31: 485-499. PMID: 37054671, PMCID: PMC10125260, DOI: 10.1016/j.chom.2023.03.016.Peer-Reviewed Original ResearchConceptsHost healthHost-microbe interactionsSpecies fitnessMicrobe-microbeEvolutionary implicationsMicrobial inhabitantsGut communitiesTrophic networksMicrobial communitiesTrophic levelsMammalian gutPrimary fermentersMetabolic outputDifferent microbesAmino acidsGut commensalsCooperative interactionsGut microbiomeNegative interactionsFitnessMutualismEcologyMicrobesEmergent roleCofactor
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