2025
Mapping pesticide-induced metabolic alterations in human gut bacteria
Chen L, Yan H, Di S, Guo C, Zhang H, Zhang S, Gold A, Wang Y, Hu M, Wu D, Johnson C, Wang X, Zhu J. Mapping pesticide-induced metabolic alterations in human gut bacteria. Nature Communications 2025, 16: 4355. PMID: 40348778, PMCID: PMC12065874, DOI: 10.1038/s41467-025-59747-6.Peer-Reviewed Original ResearchConceptsModulating gut microbiota compositionGut bacteria speciesGut microbial speciesHuman gut bacteriaGut microbiota compositionGut bacterial metabolismPesticide exposureHost healthGut bacteriaMicrobiota compositionMicrobial speciesBacterial metabolismBacteria speciesMolecular mechanismsComprehensive atlasLipid metabolismGutIn Vivo Mouse ModelPesticidesHostMetabolismSpeciesInteractive atlasMouse modelMetabolic changes
2024
Laboratory Management of Mammalian Hosts for Ixodes scapularis -Host-Pathogen Interaction Studies.
Narasimhan S, Cibichakravarthy B, Wu M, Holter M, Walsh C, Goodrich J. Laboratory Management of Mammalian Hosts for Ixodes scapularis -Host-Pathogen Interaction Studies. Journal Of The American Association For Laboratory Animal Science 2024, 74: 235-245. PMID: 39289828, PMCID: PMC11373684, DOI: 10.30802/aalas-cm-24-036.Peer-Reviewed Original ResearchConceptsTick feedingHard-bodied ticksTick speciesArtificial membrane feedingHard ticksMammalian hostsAnimal healthHost-pathogen interaction studiesIxodes scapularisTicksManagement practicesNatural geographic rangePotential vectorsRabbit hostsFeedingHost healthGeographic rangePathogenic organismsInfectious prionsAnimal useRelevant speciesIxodesGuinea pigsLife cycleInteraction studiesLongitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease
Zhou X, Shen X, Johnson J, Spakowicz D, Agnello M, Zhou W, Avina M, Honkala A, Chleilat F, Chen S, Cha K, Leopold S, Zhu C, Chen L, Lyu L, Hornburg D, Wu S, Zhang X, Jiang C, Jiang L, Jiang L, Jian R, Brooks A, Wang M, Contrepois K, Gao P, Rose S, Tran T, Nguyen H, Celli A, Hong B, Bautista E, Dorsett Y, Kavathas P, Zhou Y, Sodergren E, Weinstock G, Snyder M. Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease. Cell Host & Microbe 2024, 32: 506-526.e9. PMID: 38479397, PMCID: PMC11022754, DOI: 10.1016/j.chom.2024.02.012.Peer-Reviewed Original ResearchHost healthMicrobiome dynamicsBacterial taxaBody sitesMicrobiome stabilityIndividual taxaHuman microbiomeMicrobial compositionMicrobial dynamicsMulti-OmicsNasal microbiomeMicrobiomeDisrupt interactionsMolecular markersBody-sitesTaxaHostMetabolic diseasesOral microbiomeInsulin-resistant individualsIndividual-specificTemporal dynamicsClinical featuresComprehensive viewClinical markers
2023
Cross-feeding in the gut microbiome: Ecology and mechanisms
Culp E, Goodman A. Cross-feeding in the gut microbiome: Ecology and mechanisms. Cell Host & Microbe 2023, 31: 485-499. PMID: 37054671, PMCID: PMC10125260, DOI: 10.1016/j.chom.2023.03.016.Peer-Reviewed Original ResearchConceptsHost healthHost-microbe interactionsSpecies fitnessMicrobe-microbeEvolutionary implicationsMicrobial inhabitantsGut communitiesTrophic networksMicrobial communitiesTrophic levelsMammalian gutPrimary fermentersMetabolic outputDifferent microbesAmino acidsGut commensalsCooperative interactionsGut microbiomeNegative interactionsFitnessMutualismEcologyMicrobesEmergent roleCofactor
2022
A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond
Medley BJ, Leclaire L, Thompson N, Mahoney KE, Pluvinage B, Parson MAH, Burke JE, Malaker S, Wakarchuk W, Boraston AB. A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond. Journal Of Biological Chemistry 2022, 298: 102439. PMID: 36049519, PMCID: PMC9513282, DOI: 10.1016/j.jbc.2022.102439.Peer-Reviewed Original ResearchConceptsUncharacterized proteinsCarbohydrate-binding moduleHuman gut microbiotaHost adaptationSubstrate recognitionCatalytic motifN-terminalHost healthGut environmentPeptidase activityHost mucinsNutrient sourceAkkermansia muciniphilaEnzymeKey membersPeptide bondProteinBacteriumActive siteGut microbiotaTn antigenPeptide backboneGenesMicrobes
2020
Landscape-level toxicant exposure mediates infection impacts on wildlife populations
Sánchez C, Altizer S, Hall R. Landscape-level toxicant exposure mediates infection impacts on wildlife populations. Biology Letters 2020, 16: 20200559. PMID: 33202181, PMCID: PMC7728674, DOI: 10.1098/rsbl.2020.0559.Peer-Reviewed Original ResearchConceptsEffects of toxicantsContaminated habitatsWildlife populationsToxicant exposureSublethal effects of toxicantsDensity of infected hostsAnthropogenic landscape modificationImpact of pathogensWildlife movementUncontaminated habitatsSublethal effectsHost declinesLandscape modificationWildlife diseasesWildlifeHabitatExposure riskUrban landscapeLandscapeHost populationsHealth effectsToxic effectsHost healthPathogen transmissionReduced survival
2011
Wild immunology: converging on the real world
Babayan S, Allen J, Bradley J, Geuking M, Graham A, Grencis R, Kaufman J, McCoy K, Paterson S, Smith K, Turnbaugh P, Viney M, Maizels R, Pedersen A. Wild immunology: converging on the real world. Annals Of The New York Academy Of Sciences 2011, 1236: 17-29. PMID: 22032399, DOI: 10.1111/j.1749-6632.2011.06251.x.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply