2025
Constrained optimization of scaffold behavior for improving tissue engineered vascular grafts
Hsu R, Szafron J, Carvalho C, Humphrey J, Marsden A. Constrained optimization of scaffold behavior for improving tissue engineered vascular grafts. Journal Of Biomechanics 2025, 186: 112670. PMID: 40286630, PMCID: PMC12085276, DOI: 10.1016/j.jbiomech.2025.112670.Peer-Reviewed Original ResearchConceptsTissue Engineered Vascular GraftsDesign parametersFunctions of native blood vesselsNative blood vesselsVascular graftsRelevant failure modesScaffold microstructureCompliance matchingMechanical behaviorBiodegradable scaffoldsLoad transferFailure modesExperimental testsOptimal designDegradation kineticsNumerical optimizationRemodeling outcomesConstrained optimizationVessel complianceDesignGraft remodelingFavorable characteristicsNeotissueIn silico frameworkParametersBiomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling
Holzapfel G, Humphrey J, Ogden R. Biomechanics of soft biological tissues and organs, mechanobiology, homeostasis and modelling. Journal Of The Royal Society Interface 2025, 22: 20240361. PMID: 39876788, PMCID: PMC11775666, DOI: 10.1098/rsif.2024.0361.Peer-Reviewed Original ResearchConceptsSoft biological tissuesConstitutive relationsLoad-bearing soft tissuesNonlinear stress analysisMethods of continuum mechanicsInelastic constitutive relationsBiomechanics of soft biological tissueDiverse loading conditionsBiological tissuesConstitutive formulationLocal mechanical environmentMechanical behaviorStress analysisLoading conditionsContinuum mechanicsMechanical responseDiverse microstructuresMulti-axialMechanical environmentMechanobiologyTissue propertiesBiomechanical studiesClinical interventionsExperimental findingsMicrostructure
2023
Decellularization compromises mechanical and structural properties of the native trachea
Greaney A, Ramachandra A, Yuan Y, Korneva A, Humphrey J, Niklason L. Decellularization compromises mechanical and structural properties of the native trachea. Biomaterials And Biosystems 2023, 9: 100074. PMID: 36967724, PMCID: PMC10036236, DOI: 10.1016/j.bbiosy.2023.100074.Peer-Reviewed Original ResearchMechanical behaviorGraft failureNative tracheaMechanical failureTissue engineering technologyDepletion of proteoglycansAirway narrowingAirway replacementClinical interventionsWestern blotTracheaMajor causeTracheal graftsEngineering technologyHistological stainingTracheal replacementDifferent decellularization protocolsSignificant differencesClinical implantationTissue repairCollagen IStructural deteriorationStructural propertiesDecellularization protocolGreat potential
2022
Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading
Staddon M, Murrell M, Banerjee S. Interplay between substrate rigidity and tissue fluidity regulates cell monolayer spreading. Soft Matter 2022, 18: 7877-7886. PMID: 36205535, PMCID: PMC9700261, DOI: 10.1039/d2sm00757f.Peer-Reviewed Original ResearchConceptsSubstrate rigidityCollective cell motionSubstrate stiffnessTissue fluidityStiff substratesCell-matrix adhesionTraction force generationCell-cell interactionsCell motionTissue morphogenesisSoft elastic matrixCell collectivesEmbryonic developmentCell crawlingCell spreadingCell monolayersSolid tissuesCell behaviorMechanical behaviorPredictive understandingMechanical propertiesCancer invasionCell aggregatesElastic matrixCell propertiesMechanical Resilience of Biofilms toward Environmental Perturbations Mediated by Extracellular Matrix
Zhang Q, Nguyen D, Tai J, Xu X, Nijjer J, Huang X, Li Y, Yan J. Mechanical Resilience of Biofilms toward Environmental Perturbations Mediated by Extracellular Matrix. Advanced Functional Materials 2022, 32 DOI: 10.1002/adfm.202110699.Peer-Reviewed Original ResearchMechanical resilienceNonlinear viscoelastic behaviorMaterials science pointLarge shear forcesBiofilm removal strategiesMechanical behaviorViscoelastic materialsViscoelastic behaviorBiofilm mechanicsSoft materialsStructure-property relationshipsRheological regimesRheological measurementsShear forceFunctional soft materialsLarge mechanical perturbationsPhysical insightPolymeric networkRemoval strategiesDynamics simulationsMolecular dynamics simulationsMaterialsDynamic environmentMatrixMechanical perturbationsNonlinear inclusion theory with application to the growth and morphogenesis of a confined body
Li J, Kothari M, Chockalingam S, Henzel T, Zhang Q, Li X, Yan J, Cohen T. Nonlinear inclusion theory with application to the growth and morphogenesis of a confined body. Journal Of The Mechanics And Physics Of Solids 2022, 159: 104709. DOI: 10.1016/j.jmps.2021.104709.Peer-Reviewed Original ResearchApproximate equilibrium solutionsMinimal analytical modelFinite element computationsJ.D. EshelbyInclusion theoryEquilibrium solutionNonlinear material responseOnset of damageCelebrated contributionsElement computationsTheoretical difficultiesTransformation of shapePhase transitionHomogenization methodFracture mechanicsExperimental observationsMechanical behaviorMaterial responseLarge deformationAnalytical modelMaterial systemElastic stressesTransformation strainMechanicsTheoretical model
2010
Surface muscle pressure as a measure of active and passive behavior of muscles during gait
Yungher DA, Wininger MT, Barr JB, Craelius W, Threlkeld AJ. Surface muscle pressure as a measure of active and passive behavior of muscles during gait. Medical Engineering & Physics 2010, 33: 464-471. PMID: 21176884, DOI: 10.1016/j.medengphy.2010.11.012.Peer-Reviewed Original ResearchConceptsSurface electromyographyMuscle pressureMuscle activity onsetIsometric knee extensionHigh intra-class correlationHealthy subjectsIntra-class correlationIsometric contractionKnee extensionMuscle stiffnessElectrical activityMuscleMechanical behaviorGaitGait cyclePressure sensorCessation timeMuscular forceActivity onsetMechanical modelSEMG waveformsRadial pressureOnsetSubjectsSingle subject
2009
Reduced nucleus pulposus glycosaminoglycan content alters intervertebral disc dynamic viscoelastic mechanics
Boxberger JI, Orlansky AS, Sen S, Elliott DM. Reduced nucleus pulposus glycosaminoglycan content alters intervertebral disc dynamic viscoelastic mechanics. Journal Of Biomechanics 2009, 42: 1941-1946. PMID: 19539936, PMCID: PMC2756063, DOI: 10.1016/j.jbiomech.2009.05.008.Peer-Reviewed Original ResearchConceptsDynamic stiffnessCompressive loadEquilibrium loadHigh dynamic stiffnessDynamic loading regimesPhase angleDynamic viscoelastic propertiesMechanical behaviorAxial loadViscoelastic mechanicsOscillatory loadingLoading regimesLow loadViscoelastic propertiesDynamic mechanicsLumbar motion segmentsMechanical mechanismDisc mechanicsStiffnessLoadSpectrum of frequenciesPossible mechanical mechanismsReduced glycosaminoglycansMotion segmentsMechanics
2006
Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments
Boxberger JI, Sen S, Yerramalli CS, Elliott DM. Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments. Journal Of Orthopaedic Research® 2006, 24: 1906-1915. PMID: 16865712, DOI: 10.1002/jor.20221.Peer-Reviewed Original Research
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