2025
Constrained optimization of scaffold behavior for improving tissue engineered vascular grafts
Hsu R, Szafron J, Carvalho C, Humphrey J, Marsden A. Constrained optimization of scaffold behavior for improving tissue engineered vascular grafts. Journal Of Biomechanics 2025, 186: 112670. PMID: 40286630, PMCID: PMC12085276, DOI: 10.1016/j.jbiomech.2025.112670.Peer-Reviewed Original ResearchConceptsTissue Engineered Vascular GraftsDesign parametersFunctions of native blood vesselsNative blood vesselsVascular graftsRelevant failure modesScaffold microstructureCompliance matchingMechanical behaviorBiodegradable scaffoldsLoad transferFailure modesExperimental testsOptimal designDegradation kineticsNumerical optimizationRemodeling outcomesConstrained optimizationVessel complianceDesignGraft remodelingFavorable characteristicsNeotissueIn silico frameworkParameters
2016
Tissue-Engineered Small Diameter Arterial Vascular Grafts from Cell-Free Nanofiber PCL/Chitosan Scaffolds in a Sheep Model
Fukunishi T, Best CA, Sugiura T, Shoji T, Yi T, Udelsman B, Ohst D, Ong CS, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Tissue-Engineered Small Diameter Arterial Vascular Grafts from Cell-Free Nanofiber PCL/Chitosan Scaffolds in a Sheep Model. PLOS ONE 2016, 11: e0158555. PMID: 27467821, PMCID: PMC4965077, DOI: 10.1371/journal.pone.0158555.Peer-Reviewed Original ResearchConceptsMechanical propertiesPCL/chitosan scaffoldsNeotissue formationSmall diameter prosthetic graftsMechanical analysisVascular graftsElectrospun polycaprolactoneChitosan scaffoldsBiodegradable scaffoldsTEVGsArterial vascular graftsBlend nanofibersFast degradationPolycaprolactoneWall thicknessScaffoldsOriginal scaffoldMaterialsHost cell infiltrationPropertiesNanofibersMatrix constituentsNeotissuePatient's own cellsMacrophage infiltration
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