2022
LBSAT59 Overnight Metyrapone Test And Urine Steroid Profiling In Patients Treated With Chronic Opioid Therapy: Prevalence Of Adrenal Insufficiency
Saini J, Gilliam W, Cunningham J, Thangamuthu K, Gruber L, Singh S, Sutor B, Hooten W, Bancos I. LBSAT59 Overnight Metyrapone Test And Urine Steroid Profiling In Patients Treated With Chronic Opioid Therapy: Prevalence Of Adrenal Insufficiency. Journal Of The Endocrine Society 2022, 6: a45-a46. PMCID: PMC9626924, DOI: 10.1210/jendso/bvac150.094.Peer-Reviewed Original ResearchOpioid-induced adrenal insufficiencyOvernight metyrapone testUrine steroid profileMetyrapone testExposure to opioidsDehydroepiandrosterone sulfateSteroid profileOpioid therapyAdrenal insufficiencyDiagnosis of adrenal disordersPrevalence of adrenal insufficiencyPatients treated with opioidsMorphine milligram equivalents (MME)/dayTreated with high dosesChronic opioid therapyMeasurement of ACTHDehydroepiandrosterone sulfate concentrationsCumulative opioid exposureQuality-of-life surveyChronic opioidsCross-sectional studyOpioid exposureAdrenal disordersSteroid metabolomeDaily MME
2001
Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications
Vgontzas A, Bixler E, Lin H, Prolo P, Mastorakos G, Vela-Bueno A, Kales A, Chrousos G. Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 3787-3794. PMID: 11502812, DOI: 10.1210/jcem.86.8.7778.Peer-Reviewed Original ResearchConceptsHypothalamic-pituitary-adrenal axisChronic insomniaCortisol secretionSleep disturbanceObjective sleep disturbancesIncrease of ACTHYoung insomniacsChronic anxietyAssociated with increased plasma levelsEmotional arousalMental disordersCircadian disturbancesInsomniacsMeasurement of ACTHInsomniaDegree of sleep disturbanceBody mass indexSleep lossAmount of cortisolClinical implicationsPulsatility analysisHealthy controlsSleep disordersDisordersArousal
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