Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications
Vgontzas A, Bixler E, Lin H, Prolo P, Mastorakos G, Vela-Bueno A, Kales A, Chrousos G. Chronic Insomnia Is Associated with Nyctohemeral Activation of the Hypothalamic-Pituitary-Adrenal Axis: Clinical Implications. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 3787-3794. PMID: 11502812, DOI: 10.1210/jcem.86.8.7778.Peer-Reviewed Original ResearchConceptsHypothalamic-pituitary-adrenal axisChronic insomniaCortisol secretionSleep disturbanceObjective sleep disturbancesIncrease of ACTHYoung insomniacsChronic anxietyAssociated with increased plasma levelsEmotional arousalMental disordersCircadian disturbancesInsomniacsMeasurement of ACTHInsomniaDegree of sleep disturbanceBody mass indexSleep lossAmount of cortisolClinical implicationsPulsatility analysisHealthy controlsSleep disordersDisordersArousal
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