Evidence for coopetition at the maternal-fetal interface shaping placental invasion.
Afzal J, Suhail Y, Du W, Liu Y, Ramasamy R, Liu Z, Goyal R, Novin A, Suhail S, Maziarz J, Wali K, Robson P, Wagner G, Kshitiz. Evidence for coopetition at the maternal-fetal interface shaping placental invasion. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2323038122. PMID: 40906814, PMCID: PMC12435225, DOI: 10.1073/pnas.2323038122.Peer-Reviewed Original ResearchConceptsMaternal-fetal interfaceExtravillous trophoblast cellsEndometrial stromal fibroblastsInvasive placentationInvasive extravillous trophoblast cellsExpression of suppressor of cytokine signaling 3IL-11 signalingResistance to invasionTrophoblast stem cellsSuppressor of cytokine signaling 3AP-1 signalingMaternal-fetal conflictMaternal stromaCytokine signaling 3Placental invasionFetal genesCytotrophoblast cellsDecidual transformationEvolutionary interestTrophoblast cellsStromal fibroblastsHemochorial placentationEutherian mammalsIL-11Paracrine signaling
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