1999
Rapid Communication CCR5 Genotype and Resistance to Vertical Transmission of HIV-1
Philpott S, Burger H, Charbonneau T, Grimson R, Vermund S, Visosky A, Nachman S, Kovacs A, Tropper P, Frey H, Weiser B. Rapid Communication CCR5 Genotype and Resistance to Vertical Transmission of HIV-1. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1999, 21: 189-193. PMID: 10421241, DOI: 10.1097/00126334-199907010-00002.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1Vertical transmissionCCR5 genotypeHIV-1 infection statusHIV-1 vertical transmissionHIV-1-infected mothersPrimary HIV-1 infectionMacrophage-tropic strainsAfrican AmericansParenteral transmissionUninfected childrenChild transmissionInfected childrenInfected mothersInfected womenDelta32 mutationCCR5 receptorInfection statusWhite childrenCCR5MothersChildrenHomozygous genotypeAdditional strategies
1998
Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5
Martin M, Dean M, Smith M, Winkler C, Gerrard B, Michael N, Lee B, Doms R, Margolick J, Buchbinder S, Goedert J, O'Brien T, Hilgartner M, Vlahov D, O'Brien S, Carrington M. Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5. Science 1998, 282: 1907-1911. PMID: 9836644, DOI: 10.1126/science.282.5395.1907.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAllelesChemokine CXCL12Chemokines, CXCCohort StudiesDisease ProgressionGenes, DominantGenes, RecessiveGenetic Predisposition to DiseaseGenotypeHaplotypesHeterozygoteHIV InfectionsHIV-1HomozygoteHumansPromoter Regions, GeneticProportional Hazards ModelsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CytokineRisk FactorsSurvival RateConceptsAIDS progressionCell-surface chemokine receptor moleculeCCR5 regulatory regionsChemokine receptor moleculesPercent of patientsAIDS disease progressionHIV-1 infectionCohort of peopleMacrophage-tropic strainsAIDS restriction genesDistinct regulatory influencesCCR2-64IPrincipal coreceptorImmunodeficiency syndromeCCR5-Delta32Genetic epidemiologic analysisDisease progressionHuman immunodeficiencySDF1-3'APromoter genotypeCCR5 geneInfected individualsEpidemiologic analysisHost factorsProgressionA Tyrosine-Rich Region in the N Terminus of CCR5 Is Important for Human Immunodeficiency Virus Type 1 Entry and Mediates an Association between gp120 and CCR5
Farzan M, Choe H, Vaca L, Martin K, Sun Y, Desjardins E, Ruffing N, Wu L, Wyatt R, Gerard N, Gerard C, Sodroski J. A Tyrosine-Rich Region in the N Terminus of CCR5 Is Important for Human Immunodeficiency Virus Type 1 Entry and Mediates an Association between gp120 and CCR5. Journal Of Virology 1998, 72: 1160-1164. PMID: 9445013, PMCID: PMC124591, DOI: 10.1128/jvi.72.2.1160-1164.1998.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1CCR5 mutantsHuman immunodeficiency virus type 1 (HIV-1) entryHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus entryDual-tropic variantsSpecific chemokine receptorsChemokine receptor CCR5Macrophage-tropic strainsVirus type 1Region of CCR5Wild-type CCR5Gp120 envelope glycoproteinInfection of cellsMacrophage-tropicAsymptomatic stageChemokine receptorsReceptor CCR5Gp120 glycoproteinCCR5Type 1InfectionEnvelope glycoprotein
1997
HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*
Farzan M, Choe H, Martin K, Sun Y, Sidelko M, Mackay C, Gerard N, Sodroski J, Gerard C. HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5*. Journal Of Biological Chemistry 1997, 272: 6854-6857. PMID: 9054370, DOI: 10.1074/jbc.272.11.6854.Peer-Reviewed Original ResearchConceptsHIV-1 entryInflammatory protein-1betaChemokine receptor CCR5Viral entryReceptor CCR5Macrophage inflammatory protein-1βHuman immunodeficiency virus type 1Immunodeficiency virus type 1Ability of CCR5Only viral entrySpecific chemokine receptorsInflammatory protein-1βMacrophage-tropic strainsVirus type 1Wild-type CCR5CCR5 mutantsMCP-1Asymptomatic stageChemokine receptorsHIV-1CCR5Virus life cycleChemokine signalingType 1Target cells
1996
Identification of a major co-receptor for primary isolates of HIV-1
Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Marzio P, Marmon S, Sutton R, Hill C, Davis C, Peiper S, Schall T, Littman D, Landau N. Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996, 381: 661-666. PMID: 8649511, DOI: 10.1038/381661a0.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply