2024
CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy
Ota M, Hoehn K, Fernandes-Braga W, Ota T, Aranda C, Friedman S, Miranda-Waldetario M, Redes J, Suprun M, Grishina G, Sampson H, Malbari A, Kleinstein S, Sicherer S, Curotto de Lafaille M. CD23+IgG1+ memory B cells are poised to switch to pathogenic IgE production in food allergy. Science Translational Medicine 2024, 16: eadi0673. PMID: 38324641, PMCID: PMC11008013, DOI: 10.1126/scitranslmed.adi0673.Peer-Reviewed Original ResearchConceptsMemory B cellsB cellsIgE-producing cellsPeanut allergySerum peanut-specific IgEFood allergyInterleukin-4 (IL-4)-B cell memoryPeanut-specific IgEAllergen-specific immunoglobulin EHigh-affinity B cellsPersistent IgE responsesConcentration of IgESingle-cell RNA sequencing experimentsMemory populationRNA sequencing experimentsIgE productionImmune responseImmunoglobulin ECirculating ConcentrationsIgE responseAllergySequencing experimentsAra h 2Long-term persistence
2022
Genome Engineering for Next-Generation Cellular Immunotherapies
Park JJ, Lee KAV, Lam SZ, Tang K, Chen S. Genome Engineering for Next-Generation Cellular Immunotherapies. Biochemistry 2022, 62: 3455-3464. PMID: 35930700, PMCID: PMC11320893, DOI: 10.1021/acs.biochem.2c00340.Peer-Reviewed Original ResearchConceptsGenome engineeringCellular immunotherapySynthetic biology approachesKnockout of genesGenome engineering approachesGenetic screening approachCell therapyNK cell therapyCAR-NK cellsBiology approachHost-graft interactionsNovel target discoveryLong-term persistenceImmune cell typesCRISPR-CasFuture therapeutic developmentTarget discoveryGenetic modificationCell typesAllogeneic contextTumor effect
2021
Plague risk in the western United States over seven decades of environmental change
Carlson C, Bevins S, Schmid B. Plague risk in the western United States over seven decades of environmental change. Global Change Biology 2021, 28: 753-769. PMID: 34796590, PMCID: PMC9299200, DOI: 10.1111/gcb.15966.Peer-Reviewed Original ResearchConceptsWestern United StatesRodent communitiesSpillover riskRodent species richnessEnvironmental changesImpacts of climate changeClimate change impactsInfectious disease distributionsLong-term persistenceSpecies richnessMid-elevationsSoil biochemistryChange impactsDisease geographyChanging ClimateLong-term trendsClimate changePlague reservoirsReservoirs of plagueWildlife reservoirsSpillover eventsInterannual variationsPlague ecologyClimateHuman cases
2020
Local persistence of novel regional variants of La Crosse virus in the Northeast USA
Eastwood G, Shepard J, Misencik M, Andreadis T, Armstrong P. Local persistence of novel regional variants of La Crosse virus in the Northeast USA. Parasites & Vectors 2020, 13: 569. PMID: 33176861, PMCID: PMC7659055, DOI: 10.1186/s13071-020-04440-4.Peer-Reviewed Original ResearchConceptsHuman casesMosquito-borne virusLa Crosse virusPediatric encephalitisField-collected mosquitoesLACV infectionConclusionOur analysisLocal mosquito populationsVirusPublic healthVirus lineagesLACVNew York StateMosquito populationsMosquitoesEncephalitisIsolatesLong-term persistenceInfectionPrevalenceCases
2018
Population genomics through time provides insights into the consequences of decline and rapid demographic recovery through head‐starting in a Galapagos giant tortoise
Jensen E, Edwards D, Garrick R, Miller J, Gibbs J, Cayot L, Tapia W, Caccone A, Russello M. Population genomics through time provides insights into the consequences of decline and rapid demographic recovery through head‐starting in a Galapagos giant tortoise. Evolutionary Applications 2018, 11: 1811-1821. PMID: 30459831, PMCID: PMC6231475, DOI: 10.1111/eva.12682.Peer-Reviewed Original ResearchGiant tortoisesBottleneck eventsGenetic diversityGenetic variationPopulation declineTortoise populationsPopulation sizeCurrent genetic diversityEffective population sizePopulation genetics theoryWide single nucleotide polymorphism dataCaptive breeding programsRapid demographic recoveryRecent population declineSingle nucleotide polymorphism dataGalapagos giant tortoisesNucleotide polymorphism dataRapid population declineLarge population sizesPopulation genomicsSpecies restorationLong-term persistencePopulation structureGenetic patternsGenetic theorySpores and soil from six sides: interdisciplinarity and the environmental biology of anthrax (Bacillus anthracis)
Carlson C, Getz W, Kausrud K, Cizauskas C, Blackburn J, Carrillo F, Colwell R, Easterday W, Ganz H, Kamath P, Økstad O, Turner W, Kolstø A, Stenseth N. Spores and soil from six sides: interdisciplinarity and the environmental biology of anthrax (Bacillus anthracis). Biological Reviews 2018, 93: 1813-1831. PMID: 29732670, DOI: 10.1111/brv.12420.Peer-Reviewed Original ResearchConceptsEnvironmental persistenceLong Term Ecological Research siteBiology of Bacillus anthracisBacillus cereus biovar anthracisPatterns of vegetationEtosha National ParkEcological Research siteEnvironmentally transmitted diseasesLong-term persistenceAnthrax riskAnthrax seasonalityHerbivorous hostsDecades of surveillanceHerbivore communitiesAnthrax dynamicsEcosystem structureConservation effortsCarcass depositionNational ParkEcological roleSpore banksDisease ecologyGreen-upHerbivoresSoil
2017
Closely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections
Rynkiewicz EC, Brown J, Tufts DM, Huang CI, Kampen H, Bent SJ, Fish D, Diuk-Wasser MA. Closely-related Borrelia burgdorferi (sensu stricto) strains exhibit similar fitness in single infections and asymmetric competition in multiple infections. Parasites & Vectors 2017, 10: 64. PMID: 28166814, PMCID: PMC5292797, DOI: 10.1186/s13071-016-1964-9.Peer-Reviewed Original ResearchConceptsAsymmetric competitive interactionsPatterns of coexistenceBiotic contextCommon disease vectorPathogen communitiesVector-Borne PathogensBorrelia burgdorferiLong-term persistencePathogen speciesAsymmetric competitionPathogen dynamicsInfection phenotypesSimilar fitnessTransmission phenotypeDisease vectorsTemperate regionsCompetitive interactionsTransmission advantagePathogen strainsPathogen persistenceBlack-legged tickCompetitive strainsPeromyscus leucopusWhite-footed miceHost
1998
Human Immunodeficiency Virus Type 1 Vectors Efficiently Transduce Human Hematopoietic Stem Cells
Sutton R, Wu H, Rigg R, Böhnlein E, Brown P. Human Immunodeficiency Virus Type 1 Vectors Efficiently Transduce Human Hematopoietic Stem Cells. Journal Of Virology 1998, 72: 5781-5788. PMID: 9621037, PMCID: PMC110379, DOI: 10.1128/jvi.72.7.5781-5788.1998.Peer-Reviewed Original ResearchConceptsHuman hematopoietic stem cellsHematopoietic stem cellsStem cellsMarker gene expressionLentivirus vector systemGene transfer agentsMarker gene productLong-term persistenceGene productsGene expressionHuman immunodeficiency virus type 1 vectorsIntegrated provirusStable expressionVector systemTransduction ratesCellsExpressionHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1MitosisTransductionDeletionOncoretrovirusesVpr
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply