2024
Nonlinearity of the inverse relationship between high-density lipoprotein (HDL) cholesterol and incident cardiovascular risk: Is it time to revisit the “HDL hypothesis”?
Hashem C, Altin S, Guyton J, Boden W. Nonlinearity of the inverse relationship between high-density lipoprotein (HDL) cholesterol and incident cardiovascular risk: Is it time to revisit the “HDL hypothesis”? Journal Of Clinical Lipidology 2024, 19: 238-246. PMID: 39934033, DOI: 10.1016/j.jacl.2024.12.009.Peer-Reviewed Original ResearchLow HDL-CHDL-C levelsHDL-CAssociated with atherosclerotic cardiovascular diseaseRandomized Controlled TrialsLow levels of high-density lipoprotein cholesterolLow HDL-C levelsLevels of high-density lipoprotein cholesterolIncident cardiovascular riskLevels of HDL-CReduce ASCVD eventsHigh-density lipoprotein cholesterolOptimal risk stratificationHigh-density lipoprotein (HDLStatin-based therapyHDL hypothesisAtherosclerotic cardiovascular diseaseLipoprotein (HDLRisk-enhancing factorsIncident cardiovascular eventsCholesterol guidelinesRisk stratificationCardiovascular eventsLipoprotein cholesterolCardiovascular risk
2021
Associations between Fasting Duration, Timing of First and Last Meal, and Cardiometabolic Endpoints in the National Health and Nutrition Examination Survey
Wirth M, Zhao L, Turner-McGrievy G, Ortaglia A. Associations between Fasting Duration, Timing of First and Last Meal, and Cardiometabolic Endpoints in the National Health and Nutrition Examination Survey. Nutrients 2021, 13: 2686. PMID: 34444846, PMCID: PMC8397975, DOI: 10.3390/nu13082686.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyNighttime fasting durationNutrition Examination SurveyCardiometabolic endpointsExamination SurveyLow HDLAssociated with higher HbA1cFasting durationOne-hour increaseCross-sectional dataPublic health datasetsCardiometabolic benefitsHealth datasetsHigh-density lipoprotein (HDLC-reactive proteinSurvey design proceduresLow-density lipoprotein (LDLHigher HbA1cLogistic regressionLipoprotein (HDLLipoprotein (LDLHbA1c %Glycosylated hemoglobinLower LDL
2019
Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity
de Lima-Junior J, Virginio V, Moura F, Bertolami A, Bertolami M, Coelho-Filho O, Zanotti I, Nadruz W, de Faria E, de Carvalho L, Sposito A. Excess weight mediates changes in HDL pool that reduce cholesterol efflux capacity and increase antioxidant activity. Nutrition Metabolism And Cardiovascular Diseases 2019, 30: 254-264. PMID: 31753789, DOI: 10.1016/j.numecd.2019.09.017.Peer-Reviewed Original ResearchConceptsCarotid intima-media thicknessBody mass indexCholesterol efflux capacityReduced cholesterol efflux capacityNon-diabetic individualsNon-obeseHDL-CIncreased values of BMIAtherosclerotic burdenEfflux capacityValues of body mass indexElevation of body mass indexProtective function of HDLIncreased BMIObesity-related declineInhibition of platelet aggregationHigh-density lipoprotein (HDLIncreased atherosclerotic burdenAssociated with carotid intima-media thicknessIncreased HDL-CDecreased HDL concentrationIntima-media thicknessFunction of HDLLipoprotein (HDLPlatelet aggregation inhibition
2018
High-density lipoprotein carbamylation and dysfunction in vascular disease.
Santana J, Brown C. High-density lipoprotein carbamylation and dysfunction in vascular disease. Frontiers In Bioscience-Landmark 2018, 23: 2227-2234. PMID: 29772557, DOI: 10.2741/4701.Peer-Reviewed Original ResearchConceptsIrreversible post-translational modification of proteinsPost-translational modification of proteinsIrreversible post-translational modificationModification of proteinsChronic kidney diseaseAtherosclerotic cardiovascular diseaseComplex macromoleculesSusceptible to modificationCarbamylationNon-enzymaticAnti-atherogenic propertiesHDL functionCardiovascular diseaseAnti-atherogenicProgression of atherosclerotic cardiovascular diseaseHigh-density lipoprotein (HDLLife spanLipoprotein (HDLProteomicsAnti-thrombotic effects
2012
High-density lipoprotein levels are strongly associated with the recovery rate of insulin sensitivity during the acute phase of myocardial infarction: A study by euglycemic hyperinsulinemic clamp
Carvalho L, Martins N, Moura F, Cintra R, Almeida O, Quinaglia e Silva J, Sposito A, Group B. High-density lipoprotein levels are strongly associated with the recovery rate of insulin sensitivity during the acute phase of myocardial infarction: A study by euglycemic hyperinsulinemic clamp. Journal Of Clinical Lipidology 2012, 7: 24-28. PMID: 23351579, DOI: 10.1016/j.jacl.2012.10.003.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAge FactorsAgedBlood Chemical AnalysisFemaleGlucose Clamp TechniqueHospitalizationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInsulin ResistanceLipoproteins, HDLMagnetic Resonance ImagingMaleMiddle AgedMyocardial InfarctionSeverity of Illness IndexSex FactorsTreatment OutcomeTriglyceridesConceptsAcute phase of MIHigh HDL groupHDL groupHDL-CPhase of MIMyocardial infarctionEuglycemic hyperinsulinemic clampAcute phaseInsulin sensitivityIS indexAssociated with increased morbidityConsecutive nondiabetic patientsHyperinsulinemic clampLevels of HDL-CPlasma levels of HDL-CST-segment elevation MIHigh-density lipoprotein levelsLow HDL groupHigh-density lipoprotein (HDLHDL-C levelsPlasma HDL-CWaist circumferenceRate of ISDecrease of insulin sensitivityLipoprotein (HDL
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