2012
Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms
Law ME, Corsino PE, Jahn SC, Davis BJ, Chen S, Patel B, Pham K, Lu J, Sheppard B, Nørgaard P, Hong J, Higgins P, Kim JS, Luesch H, Law BK. Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. Oncogene 2012, 32: 1316-1329. PMID: 22543582, PMCID: PMC3773700, DOI: 10.1038/onc.2012.138.Peer-Reviewed Original ResearchConceptsE-cadherin localizationE-cadherinPlasma membraneCytoplasmic vesiclesWild-type E-cadherinBreast cancer cellsSerine protease inhibitor plasminogen activator inhibitor-1HDAC inhibitorsCancer cellsBasal-like breast cancer cellsPro-invasive activityGreen fluorescent proteinFull-length formCDCP1 cleavageAnti-invasive functionInhibitor plasminogen activator inhibitor-1MDA-MB-231 cellsHistone deacetylase inhibitorsTriple-negative breast cancerE-cadherin levelsCellular invasionE-cadherin expressionFluorescent proteinCDCP1 proteinOrthotopic xenograft tumors
2005
A Putative Role for Psoriasin in Breast Tumor Progression
Krop I, März A, Carlsson H, Li X, Bloushtain-Qimron N, Hu M, Gelman R, Sabel MS, Schnitt S, Ramaswamy S, Kleer CG, Enerbäck C, Polyak K. A Putative Role for Psoriasin in Breast Tumor Progression. Cancer Research 2005, 65: 11326-11334. PMID: 16357139, DOI: 10.1158/0008-5472.can-05-1523.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBiomarkers, TumorBreast NeoplasmsCalcium-Binding ProteinsCarcinoma, Intraductal, NoninfiltratingCollagenasesDisease ProgressionDown-RegulationFemaleHumansMatrix Metalloproteinase 13MiceMice, NudeNeovascularization, PathologicReceptors, EstrogenRNA, MessengerRNA, Small InterferingS100 Calcium Binding Protein A7S100 ProteinsTumor Cells, CulturedVascular Endothelial Growth Factor AConceptsReactive oxygen speciesInvasive breast carcinomaBreast tumor progressionVascular endothelial growth factorTumor progressionMitochondrial reactive oxygen speciesPsoriasin expressionStable short hairpin RNAShort hairpin RNAAnti-invasive functionPutative functionsHuman IBC cell linesEstrogen receptor-negative tumorsHuman invasive breast carcinomasHairpin RNAHigh psoriasin expressionIBC cell linesWorse clinical outcomesCell migrationPoor prognostic factorReceptor-negative tumorsPutative roleInhibits tumor growthMatrix metalloproteinase-13Cell proliferation
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