2022
Application of CRISPR/Cas Genomic Editing Tools for HIV Therapy: Toward Precise Modifications and Multilevel Protection
Maslennikova A, Mazurov D. Application of CRISPR/Cas Genomic Editing Tools for HIV Therapy: Toward Precise Modifications and Multilevel Protection. Frontiers In Cellular And Infection Microbiology 2022, 12: 880030. PMID: 35694537, PMCID: PMC9177041, DOI: 10.3389/fcimb.2022.880030.Peer-Reviewed Original ResearchConceptsHIV therapyViral resistance to therapyResistance to HIV infectionLatent HIV reservoirResistance to therapyMature B cellsKnock-in (KIHIV reservoirLatent HIVAntiretroviral therapyHIV infectionViral coreceptorsViral escapeFusion inhibitory peptidesDrug toxicityB cellsNeutralizing antibodiesHAARTProviral DNATherapyProvirus excisionTherapeutic methodsHIVInhibitory peptidesGene editing
2020
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR, Spivak AM, Planelles V, Hahn BH, Smith DM, Ho YC, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I, Riley JL, Tebas P, Montaner LJ. Recommendations for measuring HIV reservoir size in cure-directed clinical trials. Nature Medicine 2020, 26: 1339-1350. PMID: 32895573, PMCID: PMC7703694, DOI: 10.1038/s41591-020-1022-1.Peer-Reviewed Original ResearchCognitive disorders in people living with HIV
Winston A, Spudich S. Cognitive disorders in people living with HIV. The Lancet HIV 2020, 7: e504-e513. PMID: 32621876, DOI: 10.1016/s2352-3018(20)30107-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCognitive disordersHIV reservoirConcomitant medication useLatent HIV reservoirCohort of peopleSuch cognitive disordersHigh rateMedication useExact prevalenceHIVCognitive functionBrain compartmentsDisordersOverall wellbeingSuch interventionsInterventionReduced ratesComorbiditiesCohortPrevalenceImpairment
2018
Brief Report
Chintanaphol M, Sacdalan C, Chottanapund S, Pinyakorn S, Buranapraditkun S, Crowell TA, Kroon E, Manasnayakorn S, Chipman JG, Schacker TW, Michael N, Phanuphak N, Spudich SS, Colby DJ, Ananworanich J. Brief Report. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 79: 244-248. PMID: 30212436, PMCID: PMC6143219, DOI: 10.1097/qai.0000000000001780.Peer-Reviewed Original ResearchConceptsAcute HIV infectionAdverse eventsLN biopsyAE incidenceBiopsy-related adverse eventsInguinal lymph node biopsyProcedure-related adverse eventsLatent HIV reservoirLymph node biopsyIncidence rate ratiosInstitutional review boardAHI participantsAIDS guidelinesAntiretroviral therapyHIV reservoirNode biopsyBaseline visitHIV infectionHIV pathogenesisMedian ageHIV characteristicsImmune activationLymphoid tissueThai menNIH Division
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