2021
Cytokine profiles in severe SARS-CoV-2 infection requiring extracorporeal membrane oxygenation support
Kaman K, Azmy V, Chichra A, Britto-Leon C, Price C. Cytokine profiles in severe SARS-CoV-2 infection requiring extracorporeal membrane oxygenation support. Respiratory Medicine Case Reports 2021, 33: 101376. PMID: 33680800, PMCID: PMC7925237, DOI: 10.1016/j.rmcr.2021.101376.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenation supportMembrane oxygenation supportVV-ECMOOxygenation supportCytokine stormVeno-venous extracorporeal membrane oxygenation supportSevere SARS-CoV-2 infectionSARS-CoV-2 infectionVV-ECMO supportRefractory respiratory failureProspective cohort studyCohort of patientsInterleukin-2 receptorCytokine elevationHyperinflammatory stateECMO supportRespiratory failureCohort studyCytokine profileClinical courseInterleukin-10COVID19 patientsUnderlying pathophysiologyInterleukin-6Inflammatory response
2011
A possible role of leptin‐associated increase in soluble interleukin‐2 receptor diminishing a clinical response to infliximab in rheumatoid arthritis: Comment on the article by Klaasen et al
Shin J, Park J, Kim J. A possible role of leptin‐associated increase in soluble interleukin‐2 receptor diminishing a clinical response to infliximab in rheumatoid arthritis: Comment on the article by Klaasen et al. Arthritis & Rheumatism 2011, 63: 2833-2834. PMID: 21618200, DOI: 10.1002/art.30462.Peer-Reviewed Original Research
2010
Current and Emerging Treatment Strategies for Cutaneous T-cell Lymphoma
Lansigan F, Foss FM. Current and Emerging Treatment Strategies for Cutaneous T-cell Lymphoma. Drugs 2010, 70: 273-286. PMID: 20166766, DOI: 10.2165/11532190-000000000-00000.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaMalignant T cellsTreatment strategiesT cellsManagement of CTCLPredictable adverse effectsRapid disease controlConservative treatment strategyFront-line therapyEarly-stage diseaseIndolent clinical courseMature T-cell lymphomasStem cell transplantInterleukin-2 receptorHistone deacetylase inhibitorsSystemic chemotherapyExtracorporeal photopheresisInitial managementSézary syndromeClinical courseCurative therapyBiological therapyCell transplantMycosis fungoides
2009
IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production
Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, De Jager P, Wicker PL, Todd LS, Hafler JA. IL2RA Genetic Heterogeneity in Multiple Sclerosis and Type 1 Diabetes Susceptibility and Soluble Interleukin-2 Receptor Production. PLOS Genetics 2009, 5: e1000322. PMID: 19119414, PMCID: PMC2602853, DOI: 10.1371/journal.pgen.1000322.Peer-Reviewed Original ResearchConceptsMultiple sclerosisT1D subjectsSoluble interleukin-2 receptor productionSoluble interleukin-2 receptorOrgan-specific autoimmune disordersHealthy control subjectsInterleukin-2 receptorType 1 diabetesHuman leukocyte antigen (HLA) complexMS risk genesAutoimmune disordersControl subjectsAutoimmunity riskHealthy controlsIL2RA regionType 1Autoimmune lociRisk allelesReceptor productionCandidate gene association studiesAntigen complexGene association studiesAssociation studiesT1D.Sclerosis
1994
Intragraft Expression of Messenger RNA for Interleukin-6 and Tumor Necrosis Factor-α Is a Predictor of Rat Small Intestine Transplant Rejection
Farmer D, McDiarmid S, Kuniyoshi J, Robert M, Shaked A, Busuttil R. Intragraft Expression of Messenger RNA for Interleukin-6 and Tumor Necrosis Factor-α Is a Predictor of Rat Small Intestine Transplant Rejection. Journal Of Surgical Research 1994, 57: 138-142. PMID: 8041128, DOI: 10.1006/jsre.1994.1121.Peer-Reviewed Original ResearchConceptsSmall intestine transplantationInterleukin-6Intragraft expressionPOD 5MRNA expressionIL-6 mRNA expressionRTPCR analysisDetection of rejectionMessenger RNAPostoperative day 3Interleukin-2 receptorTumor necrosis factorUseful diagnostic adjunctTranscriptase-polymerase chain reactionBeta-scintillation countingIntestine transplantationIntestinal histopathologyPOD 8Transplant rejectionPolymerase chain reactionTumor necrosisIL-2RNecrosis factorAllograftsDiagnostic adjunct
1989
Inflammatory cerebrospinal fluid t cells have activation requirements characteristic of cd4+cd45ra‐ t cells
Chofflon M, González V, Weiner H, Hafler D. Inflammatory cerebrospinal fluid t cells have activation requirements characteristic of cd4+cd45ra‐ t cells. European Journal Of Immunology 1989, 19: 1791-1795. PMID: 2479560, DOI: 10.1002/eji.1830191005.Peer-Reviewed Original ResearchConceptsCSF T cellsPhorbol myristate acetateMononuclear cellsCSF mononuclear cellsT cellsCerebrospinal fluidCerebrospinal fluid T cellsCSF of subjectsProtein kinase CCD3/T cell receptor complexInflammatory brain diseasesBlood mononuclear cellsT cell populationsSorted T cellsInterleukin-2 receptorInterleukin-2 secretionCD2 activation pathwayT cell receptor complexKinase CInflammatory compartmentMultiple sclerosisCNS diseaseCell receptor complexImmune responseNormal subjectsLIVER MEMBRANE-SPECIFIC T CEL CLONES IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (aCAH)
Wen L, Lobo Yeo A, Pcakman M, Mowat A, Mieli Vargant G, Vargani D. LIVER MEMBRANE-SPECIFIC T CEL CLONES IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS (aCAH). Pediatric Research 1989, 26: 272-272. DOI: 10.1203/00006450-198909000-00050.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsAllogeneic peripheral blood mononuclear cellsT cell clonesIL-2Cell clonesIrradiated autologous peripheral blood mononuclear cellsAutologous peripheral blood mononuclear cellsExcess IL-2Blood mononuclear cellsAntigen presenting cellsInterleukin-2 receptorLiver cell membraneAnti-IL2RAUTOIMMUNE CHRONICAnti-CD4HLA-DRMononuclear cellsImmune attackPresenting cellsT cellsT lymphocytesPatientsRabbit kidney membranesCells/Liver membranesSIMILAR EFFECTS OF CYCLOSPORINE AND VERAPAMIL ON LYMPHOKINE, INTERLEUKIN 2 RECEPTOR, AND PROTO-ONCOGENE EXPRESSION
WALZ G, ZANKER B, WIEDER K, HADRO E, MOSCOVITCH-LOPATIN M, SMITH B, STROM T. SIMILAR EFFECTS OF CYCLOSPORINE AND VERAPAMIL ON LYMPHOKINE, INTERLEUKIN 2 RECEPTOR, AND PROTO-ONCOGENE EXPRESSION. Transplantation 1989, 47: 331-333. PMID: 2645720, DOI: 10.1097/00007890-198902000-00029.Peer-Reviewed Original ResearchConceptsT cell activationT cell mitogenesisC-MycIL-2RCultures of peripheral blood mononuclear cellsIncrease of intracellular Ca2+Calcium channel blocking agentsPeripheral blood mononuclear cellsMitogen-activated T cellsExpression of IL-2REvents of T cell activationEarly events of T cell activationEffect of cyclosporineIntracellular Ca2+Interleukin-2 receptorP55 interleukin 2 receptorChannel Blocking AgentsConcentrations of verapamilBlood mononuclear cellsCalcium-independent pathwayClinically therapeutic levelsIL-2 gene expressionProto-oncogene expressionPhorbol myristate acetateIn vitro concentrations
1987
B lymphocyte reconstitution after human bone marrow transplantation. Leu-1 antigen defines a distinct population of B lymphocytes.
Antin JH, Ault KA, Rappeport JM, Smith BR. B lymphocyte reconstitution after human bone marrow transplantation. Leu-1 antigen defines a distinct population of B lymphocytes. Journal Of Clinical Investigation 1987, 80: 325-332. PMID: 3112184, PMCID: PMC442241, DOI: 10.1172/jci113076.Peer-Reviewed Original ResearchConceptsLeu-1B cellsMarrow transplantationHuman bone marrow transplantationEffect of GVHDHuman marrow transplantationBone marrow transplantationEx vivo treatmentInterleukin-2 receptorB lymphocyte reconstitutionSeparate B cell lineageNormal B cellsB-cell lineageAcute GVHDChronic graftHost diseaseLymphocyte reconstitutionDonor originVivo treatmentB lymphocytesMultivariate analysisStages of differentiationGVHDTransplantationMarrow
1985
In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis
Hafler D, Fox D, Manning M, Schlossman S, Reinherz E, Weiner H. In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis. New England Journal Of Medicine 1985, 312: 1405-1411. PMID: 2985995, DOI: 10.1056/nejm198505303122201.Peer-Reviewed Original ResearchConceptsProgressive multiple sclerosisMultiple sclerosisInterleukin-2 receptorNervous system diseasesNeurologic diseaseSpinal fluidPeripheral bloodSystem diseasesCerebrospinal fluidInflammatory central nervous system diseasesCentral nervous system diseaseSystemic immune activationInflammatory neurologic diseasesPeripheral blood lymphocytesBlood of patientsActivated T lymphocytesAbnormal immunologic activityCent of lymphocytesCent of cellsT cell activationImmune activationT cellsT lymphocytesImmunologic activityNormal controls
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