SIMILAR EFFECTS OF CYCLOSPORINE AND VERAPAMIL ON LYMPHOKINE, INTERLEUKIN 2 RECEPTOR, AND PROTO-ONCOGENE EXPRESSION
WALZ G, ZANKER B, WIEDER K, HADRO E, MOSCOVITCH-LOPATIN M, SMITH B, STROM T. SIMILAR EFFECTS OF CYCLOSPORINE AND VERAPAMIL ON LYMPHOKINE, INTERLEUKIN 2 RECEPTOR, AND PROTO-ONCOGENE EXPRESSION. Transplantation 1989, 47: 331-333. PMID: 2645720, DOI: 10.1097/00007890-198902000-00029.Peer-Reviewed Original ResearchConceptsT cell activationT cell mitogenesisC-MycIL-2RCultures of peripheral blood mononuclear cellsIncrease of intracellular Ca2+Calcium channel blocking agentsPeripheral blood mononuclear cellsMitogen-activated T cellsExpression of IL-2REvents of T cell activationEarly events of T cell activationEffect of cyclosporineIntracellular Ca2+Interleukin-2 receptorP55 interleukin 2 receptorChannel Blocking AgentsConcentrations of verapamilBlood mononuclear cellsCalcium-independent pathwayClinically therapeutic levelsIL-2 gene expressionProto-oncogene expressionPhorbol myristate acetateIn vitro concentrations
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