2022
Improving Cancer Care for Patients With CKD: The Need for Changes in Clinical Trials
Sprangers B, Perazella MA, Lichtman SM, Rosner MH, Jhaveri KD. Improving Cancer Care for Patients With CKD: The Need for Changes in Clinical Trials. Kidney International Reports 2022, 7: 1939-1950. PMID: 36090489, PMCID: PMC9458993, DOI: 10.1016/j.ekir.2022.06.005.Peer-Reviewed Original ResearchChronic kidney diseaseEnd-stage kidney diseaseSevere kidney dysfunctionKidney diseaseKidney dysfunctionAdvanced kidney diseaseOptimal clinical careCancer drug trialsNumber of patientsNarrow therapeutic indexInitial clinical studiesKidney replacement treatmentPreregistration studiesKidney functionCancer careReplacement treatmentCancer trialsClinical trialsEffective dosingClinical studiesTreatment decisionsDrug trialsBeneficial drugsClinical carePatients
2017
Mesenchymal Stem Cells
Sasaki M, Honmou O. Mesenchymal Stem Cells. 2017, 147-156. DOI: 10.1007/978-4-431-56059-3_12.Peer-Reviewed Original ResearchIntravenous infusionMesenchymal stem cellsAdult human bone marrowHuman bone marrowAnimal modelsBone marrowInfused mesenchymal stem cellsHuman stroke patientsSpinal cord injuryInitial clinical studiesInitial human studiesStem cellsAxonal sproutingCerebral strokeStroke patientsCord injuryFunctional improvementClinical studiesTherapeutic effectStroke modelHuman studiesInfusionStrokeMarrowHuman mesenchymal stem cells
2013
Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer
Sznol M, Chen L. Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer. Clinical Cancer Research 2013, 19: 1021-1034. PMID: 23460533, PMCID: PMC3702373, DOI: 10.1158/1078-0432.ccr-12-2063.Peer-Reviewed Original ResearchConceptsB7-H1PD-1PD-1/PDAnti-PD-1 antibodyTumor microenvironmentAccurate predictive biomarkersEncouraging safety profileLigand B7-H1Antitumor immune responseB7-H1 expressionSubset of patientsImmune suppressive moleculesT cell functionInitial clinical studiesActivated T lymphocytesAdvanced human cancersRemarkable antitumor activityB7-DCClinical responseMetastatic diseaseDeath-1Immune suppressionSafety profileLung cancerPredictive biomarkers
2012
Mesenchymal stem cells: therapeutic outlook for stroke
Honmou O, Onodera R, Sasaki M, Waxman SG, Kocsis JD. Mesenchymal stem cells: therapeutic outlook for stroke. Trends In Molecular Medicine 2012, 18: 292-297. PMID: 22459358, DOI: 10.1016/j.molmed.2012.02.003.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem cellsTransplanted MSCsSpinal cord injuryInitial clinical studiesInitial human studiesBone marrow-derived mesenchymal stem cellsAdult bone marrow-derived mesenchymal stem cellsAdult human bone marrowAxonal sproutingCerebral ischemiaClinical outcomesNeuroprotective effectsCord injuryHuman bone marrowClinical studiesTherapeutic effectStroke modelAnimal modelsHuman studiesBone marrowMesenchymal stem cellsIntravenous deliveryTherapeutic outlookMSC deliveryStroke
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