2018
Targeting Protein Disulfide Isomerase with the Oral Flavonoid Isoquercetin Prevents Venous Thromboembolism in Advanced Cancer: Results of a Multi-Dose, Multi-Center, Phase II Clinical Trial (CATIQ Study)
Zwicker J, Schlechter B, Stopa J, Liebman H, Aggarwal A, Caughey T, Bauer K, Kuemmerle N, Wong E, Wun T, Mclaughlin M, Puligandla M, Neuberg D, Furie B, Flaumenhaft R. Targeting Protein Disulfide Isomerase with the Oral Flavonoid Isoquercetin Prevents Venous Thromboembolism in Advanced Cancer: Results of a Multi-Dose, Multi-Center, Phase II Clinical Trial (CATIQ Study). Blood 2018, 132: 985. DOI: 10.1182/blood-2018-99-114946.Peer-Reviewed Original ResearchVenous thromboembolismDay 56Major hemorrhageAdvanced cancerAntithrombotic efficacyCancer patientsHigh riskThrombus formationD-dimer plasma concentrationIncidence of VTEPlasma D-dimer levelsNon-small cell lungPhase II clinical trialPlatelet-dependent thrombin generationPrevent Venous ThromboembolismPhase II studySecond-line chemotherapySymptomatic pulmonary embolismD-dimer levelsLower extremity DVTPhase II trialMonths of initiationLower extremity ultrasoundSoluble P-selectinInitial human studies
2017
Mesenchymal Stem Cells
Sasaki M, Honmou O. Mesenchymal Stem Cells. 2017, 147-156. DOI: 10.1007/978-4-431-56059-3_12.Peer-Reviewed Original ResearchIntravenous infusionMesenchymal stem cellsAdult human bone marrowHuman bone marrowAnimal modelsBone marrowInfused mesenchymal stem cellsHuman stroke patientsSpinal cord injuryInitial clinical studiesInitial human studiesStem cellsAxonal sproutingCerebral strokeStroke patientsCord injuryFunctional improvementClinical studiesTherapeutic effectStroke modelHuman studiesInfusionStrokeMarrowHuman mesenchymal stem cells
2012
Mesenchymal stem cells: therapeutic outlook for stroke
Honmou O, Onodera R, Sasaki M, Waxman SG, Kocsis JD. Mesenchymal stem cells: therapeutic outlook for stroke. Trends In Molecular Medicine 2012, 18: 292-297. PMID: 22459358, DOI: 10.1016/j.molmed.2012.02.003.Peer-Reviewed Original ResearchConceptsMarrow-derived mesenchymal stem cellsTransplanted MSCsSpinal cord injuryInitial clinical studiesInitial human studiesBone marrow-derived mesenchymal stem cellsAdult bone marrow-derived mesenchymal stem cellsAdult human bone marrowAxonal sproutingCerebral ischemiaClinical outcomesNeuroprotective effectsCord injuryHuman bone marrowClinical studiesTherapeutic effectStroke modelAnimal modelsHuman studiesBone marrowMesenchymal stem cellsIntravenous deliveryTherapeutic outlookMSC deliveryStroke
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply