2025
Circulating immunoregulatory B cell and autoreactive antibody profiles predict lack of toxicity to anti-PD-1 checkpoint inhibitor treatment in advanced melanoma
Willsmore Z, Booth L, Patel A, Di Meo A, Prassas I, Chauhan J, Wu Y, Fitzpartick A, Stoker K, Kapiris M, Biswas D, Perucha E, Whittaker S, Tsoka S, Diamandis E, Middleton G, Tull T, Papa S, Lacy K, Karagiannis S. Circulating immunoregulatory B cell and autoreactive antibody profiles predict lack of toxicity to anti-PD-1 checkpoint inhibitor treatment in advanced melanoma. Journal For ImmunoTherapy Of Cancer 2025, 13: e011682. PMID: 40449958, PMCID: PMC12142029, DOI: 10.1136/jitc-2025-011682.Peer-Reviewed Original ResearchConceptsImmune-related adverse eventsAnti-PD-1 therapyStage III/IV melanomaAnti-PD-1Memory B cellsB cellsCheckpoint inhibitorsHigher IgG4Development of immune-related adverse eventsResponse to anti-PD-1 therapyClass-switched memory B cellsClass-switched B cellsAccurate predictive biomarkersDN2 B cellsExtrafollicular B cell responseCheckpoint inhibitor treatmentB cell frequenciesB cell responsesIL-10+Response to therapyIgE serum levelsImmune response profileHumoral immune response profileSerum antibody isotypesAdvanced melanoma
2013
Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer
Sznol M, Chen L. Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer. Clinical Cancer Research 2013, 19: 1021-1034. PMID: 23460533, PMCID: PMC3702373, DOI: 10.1158/1078-0432.ccr-12-2063.Peer-Reviewed Original ResearchConceptsB7-H1PD-1PD-1/PDAnti-PD-1 antibodyTumor microenvironmentAccurate predictive biomarkersEncouraging safety profileLigand B7-H1Antitumor immune responseB7-H1 expressionSubset of patientsImmune suppressive moleculesT cell functionInitial clinical studiesActivated T lymphocytesAdvanced human cancersRemarkable antitumor activityB7-DCClinical responseMetastatic diseaseDeath-1Immune suppressionSafety profileLung cancerPredictive biomarkers
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