2024
Circulating Tumor DNA Dynamics Fail to Predict Efficacy of Poly(ADP-ribose) Polymerase/VEGFR Inhibition in Patients With Heavily Pretreated Advanced Solid Tumors
Hu Y, Narayan A, Xu Y, Wolfe J, Vu D, Trinh T, Kantak C, Ivy S, Eder J, Deng Y, LoRusso P, Kim J, Patel A. Circulating Tumor DNA Dynamics Fail to Predict Efficacy of Poly(ADP-ribose) Polymerase/VEGFR Inhibition in Patients With Heavily Pretreated Advanced Solid Tumors. JCO Precision Oncology 2024, 8: e2300289. PMID: 38412387, PMCID: PMC10914240, DOI: 10.1200/po.23.00289.Peer-Reviewed Original ResearchConceptsCell-free circulating tumor DNANon-small-cell lung cancerSmall-cell lung cancerTriple-negative breast cancerPancreatic ductal adenocarcinomaAdvanced solid tumorsVariant allele fractionRadiographic responseOverall survivalCombination therapySolid tumorsCtDNA levelsLung cancerPretreated advanced solid tumorsDays of combination therapyMetastatic pancreatic ductal adenocarcinomaResponse to anticancer therapyAssociated with disease progressionProgression-free survivalPlasma samplesLead-InPoly(ADP-riboseInferior OSTumor DNASurvival outcomes
2019
Tubulointerstitial Infiltration of M2 Macrophages in Henoch‐Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters
Kim J, Choi S, Lee K, Jeong H, Shin J, Lim B. Tubulointerstitial Infiltration of M2 Macrophages in Henoch‐Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters. BioMed Research International 2019, 2019: 8579619. PMID: 30800680, PMCID: PMC6360621, DOI: 10.1155/2019/8579619.Peer-Reviewed Original ResearchConceptsClass III-IVChronic renal failureAssociated with chronic renal failureHenoch-Schonlein purpuraIII-IVISKDC classificationClinical parametersGlomerular crescentsInternational Study of Kidney DiseaseM2 macrophagesPresence of glomerular crescentsPresence of chronic renal failureAssociated with disease progressionInfiltration of M2 macrophagesInfiltration of M1Subtypes of macrophagesStudy of Kidney DiseaseTubulointerstitial infiltrationRenal involvementSystemic vasculitisISKDCRenal failureHistological featuresSevere manifestationsBorderline significance
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