Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma
Zhu G, Benayed R, Ho C, Mullaney K, Sukhadia P, Rios K, Berry R, Rubin B, Nafa K, Wang L, Klimstra D, Ladanyi M, Hameed M. Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma. Modern Pathology 2018, 32: 609-620. PMID: 30459475, PMCID: PMC6486453, DOI: 10.1038/s41379-018-0175-7.Peer-Reviewed Original ResearchConceptsRNA sequencing assayFusion partnerClinical molecular diagnostic assaySequencing assayIn-frame fusion transcriptsFusion transcriptsDetection of gene fusionsSoft tissue tumorsOncogenic fusion transcriptsAnchored multiplex PCRMolecular diagnostic assaysPseudomyogenic hemangioendotheliomaSolid tumorsTissue tumorsTumor typesClinical management of sarcomasMultiplex PCRRNA sequencingGene fusionsTRPS1-PLAG1Molecular methodsCase of pseudomyogenic hemangioendotheliomaClinical specimensRNASequencing step
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