Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway
Shrivastava S, Devhare P, Sujijantarat N, Steele R, Kwon Y, Ray R, Ray R. Knockdown of Autophagy Inhibits Infectious Hepatitis C Virus Release by the Exosomal Pathway. Journal Of Virology 2015, 90: 1387-1396. PMID: 26581990, PMCID: PMC4719613, DOI: 10.1128/jvi.02383-15.Peer-Reviewed Original ResearchConceptsHepatitis C virusInfectious hepatitis C virusInnate immune responseHCV releaseImmune responseInhibition of HCVVirus-infected hepatocytesExosomal pathwayKnockdown cellsExosome markers CD63Infectious virus particlesBST-2 geneChronic hepatitisRole of autophagyHCV RNALiver cirrhosisHCV pathogenesisC virusInfected hepatocytesViral persistenceHepatocellular carcinomaHCV assemblyMajor causeVirus transmissionPrecise mechanism
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