2024
Single-Cell Transcriptomic Analyses of Brain Parenchyma in Patients With New-Onset Refractory Status Epilepticus (NORSE)
Hanin A, Zhang L, Huttner A, Plu I, Mathon B, Bielle F, Navarro V, Hirsch L, Hafler D. Single-Cell Transcriptomic Analyses of Brain Parenchyma in Patients With New-Onset Refractory Status Epilepticus (NORSE). Neurology Neuroimmunology & Neuroinflammation 2024, 11: e200259. PMID: 38810181, PMCID: PMC11139018, DOI: 10.1212/nxi.0000000000200259.Peer-Reviewed Original ResearchConceptsNew-onset refractory status epilepticusTemporal lobe epilepsyGABAergic neuronsExcitatory neuronsInfiltrating MacrophagesProportion of GABAergic neuronsChronic temporal lobe epilepsyRefractory status epilepticusInhibitory GABAergic neuronsSingle-cell transcriptome analysisDecreased expression of genesDegree of demyelinationImmune disturbancesNeuronal excitabilityImmune dysregulationNew-onsetStatus epilepticusPoor outcomeRefractory epilepsyHealthy childrenMicroglial reactivitySingle-nucleus RNA sequencingNLRP3 inflammasome activationInflammatory responseLobe epilepsy
2017
Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells
Prytkova I, Brennand K. Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells. Frontiers In Cellular Neuroscience 2017, 11: 360. PMID: 29217999, PMCID: PMC5703699, DOI: 10.3389/fncel.2017.00360.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsInhibitory GABAergic neuronsAbnormal neuronal functionStem cellsPluripotent stem cellsGABAergic neuronsDopaminergic neuronsNetwork dysfunctionSZ pathologyDifficult disorderPatient-derived pluripotent stem cellsGlial culturesAnimal modelsNeuronal functionNetwork pathologyPatient-specific mannerHuman induced pluripotent stem cellsMolecular dysfunctionCo-culture techniqueInduced pluripotent stem cellsDysfunctionHigh rateDifferent cell typesNeuronsPathologyCell types
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