Embryonic mast cells arise from the Cpa3-expressing precursors but not granulocyte-monocyte progenitors
Ma W, Chen H, Gao F, Zhao H, Wu N, Zhang S, Zhu Y, Xu Z, Lan Y, Liu B, Ye Y, Liu Z, Ginhoux F, Su B. Embryonic mast cells arise from the Cpa3-expressing precursors but not granulocyte-monocyte progenitors. Science China Life Sciences 2025, 68: 2363-2378. PMID: 40419842, DOI: 10.1007/s11427-024-2891-1.Peer-Reviewed Original ResearchConceptsGranulocyte-monocyte progenitorsMast cellsFetal liverMC precursorsEarly yolk sacIn vivo transplantation assaysSkin mast cellsDermal mast cellsIn vitro differentiationYolk sacImmune cellsTransplantation assaysSingle-cell RNA sequencingEmbryonic dayImmunological diseasesEmbryonic hematopoiesisPeripheral tissuesHost defenseEmbryonic originConnective tissueFate mappingFunctional studiesRNA sequencingDevelopmental programLiver
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