Development of a large animal orthotopic intestinal transplantation model with long-term survival for study of immunologic outcomes
Merl S, Chen B, Gunes M, Atta H, Yang K, Ekanayake-Alper D, Hajosi D, Huang F, Bhola B, Patwardhan S, Jordache P, Nowak G, Martinez M, Kato T, Sykes M, Yamada K, Weiner J. Development of a large animal orthotopic intestinal transplantation model with long-term survival for study of immunologic outcomes. Frontiers In Transplantation 2024, 3: 1367486. PMID: 38993771, PMCID: PMC11235311, DOI: 10.3389/frtra.2024.1367486.Peer-Reviewed Original ResearchLong-term survivalAnimal modelsPostoperative management strategiesRate of rejectionInduction regimensImmunosuppressive strategiesParenteral nutritionImmunological complicationsIntestinal failureGraft functionClinical regimenImmunological outcomesPre-clinical trialsSurgical methodsIntestinal transplantationTransplantation modelFluid managementBowel positionVessel preparationITxImmunosuppressionSurvivalComplicationsImmunological analysisOutcomes
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