2022
Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis
Lin Y, Zhao Y, Zhang H, Hao W, Zhu R, Wang Y, Hu W, Zhou R. Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis. Frontiers In Immunology 2022, 13: 997621. PMID: 36275686, PMCID: PMC9580404, DOI: 10.3389/fimmu.2022.997621.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisSynovial inflammationImmune cellsCollagen antibody-induced arthritis modelAntibody-induced arthritis modelCartilage/bone destructionPathogenesis of RACommon autoimmune diseaseImmune cell functionPotential therapeutic targetIntermediate-conductance CaImmune balanceRA patientsBone destructionImmune dysfunctionChronic inflammationArthritis modelAutoimmune diseasesPeripheral bloodArticular synoviumPathological progressionCartilage damageKCa3.1 channelsTherapeutic targetAbnormal activation
1988
Immunotherapy of multiple sclerosis
Weiner H, Hafler D. Immunotherapy of multiple sclerosis. Annals Of Neurology 1988, 23: 211-222. PMID: 3288084, DOI: 10.1002/ana.410230302.Peer-Reviewed Original ResearchConceptsMultiple sclerosisClinical trialsHelper/inducer cellsOnset of progressionMultiple sclerosis therapyNumber of relapsesPresent treatment modalitiesAntigen-specific cellsActivated T cellsImmune balanceImmunotherapeutic interventionsNonspecific immunosuppressionSclerosis therapyAcute attacksAutoimmune diseasesInducer cellsLymphocyte trafficTreatment modalitiesSuppressor influencesEarly treatmentT cellsEffective treatmentTherapeutic goalsImmunotherapyImmune system
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