Identification of post-translationally modified MHC class I-associated peptides as potential cancer immunotherapeutic targets
Mahoney K, Reser L, Ruiz Cuevas M, Abelin J, Shabanowitz J, Hunt D, Malaker S. Identification of post-translationally modified MHC class I-associated peptides as potential cancer immunotherapeutic targets. Molecular & Cellular Proteomics 2025, 100971. PMID: 40239839, DOI: 10.1016/j.mcpro.2025.100971.Peer-Reviewed Original ResearchCirculating cytotoxic T-cellsMHC class I processing pathwayClass I processing pathwayCancer immunotherapy targetCytotoxic T cellsCancer immunotherapeutic targetsVaccine development effortsModern immunotherapyImmunotherapy targetMHC-associated peptidesImmunotherapeutic targetT cellsMalignant cellsAntigen presentationAberrant signalingMHC-peptideMass spectrometry-based technologiesCancerMHCPost-translational modificationsDysregulationIdentification of post-translationallyPeptideImmunotherapyPathway
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