2021
Pediatric Emergency Medicine Didactics and Simulation (PEMDAS) Telesimulation Series: Hyperleukocytosis
Koff A, Burns R, Auerbach M, Lee B, Pearce J, Ciener D, Augenstein J, Yeung C, Thomas A. Pediatric Emergency Medicine Didactics and Simulation (PEMDAS) Telesimulation Series: Hyperleukocytosis. MedEdPORTAL 2021, 17: 11205. PMID: 34963902, PMCID: PMC8666409, DOI: 10.15766/mep_2374-8265.11205.Peer-Reviewed Original ResearchConceptsPediatric emergency medicineMental statusManagement of hyperleukocytosisTumor lysis syndromeEmergency medicineAppropriate workupLysis syndromeNeurologic changesPediatric patientsPrompt recognitionRespiratory distressElectrolyte derangementsInfrequent presentationParticipant evaluation formsHyperleukocytosisPhysical distancing guidelinesMedical emergencyAppropriate interventionsInitial assessmentSimulation-based curriculumCoagulopathyPatientsFeverCOVID-19 pandemicEvaluation form
2020
Leukocytapheresis for patients with acute myeloid leukemia presenting with hyperleukocytosis and leukostasis: a contemporary appraisal of outcomes and benefits
Shallis RM, Stahl M, Bewersdorf JP, Hendrickson JE, Zeidan AM. Leukocytapheresis for patients with acute myeloid leukemia presenting with hyperleukocytosis and leukostasis: a contemporary appraisal of outcomes and benefits. Expert Review Of Hematology 2020, 13: 489-499. PMID: 32248712, DOI: 10.1080/17474086.2020.1751609.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsWhite blood cell countAcute myeloid leukemiaTumor lysis syndromeMyeloid leukemiaPeripheral white blood cell countEvidence-based clinical guidelinesTotal white blood cell countEnd-organ damageRelevant patient outcomesWide practice variationBlood cell countPeripheral myeloblastsLysis syndromeIntravascular coagulationSurvival benefitOrgan damageClinical guidelinesPatient outcomesPractice variationLeukocytapheresisHigh riskCytoreductive strategyCell countHyperleukocytosisCells/LPatterns of care and clinical outcomes of patients with newly diagnosed acute myeloid leukemia presenting with hyperleukocytosis who do not receive intensive chemotherapy
Shallis RM, Stahl M, Wei W, Montesinos P, Lengline E, Neukirchen J, Bhatt VR, Sekeres MA, Fathi AT, Konig H, Luger S, Khan I, Roboz GJ, Cluzeau T, Martínez-Cuadron D, Raffoux E, Germing U, Umakanthan JM, Mukhereje S, Brunner AM, Miller A, McMahon CM, Ritchie EK, Rodríguez-Veiga R, Itzykson R, Boluda B, Rabian F, Tormo M, Acuña-Cruz E, Rabinovich E, Yoo B, Cano I, Podoltsev NA, Bewersdorf JP, Gore S, Zeidan AM. Patterns of care and clinical outcomes of patients with newly diagnosed acute myeloid leukemia presenting with hyperleukocytosis who do not receive intensive chemotherapy. Leukemia & Lymphoma 2020, 61: 1220-1225. PMID: 32100599, PMCID: PMC8273667, DOI: 10.1080/10428194.2020.1728753.Peer-Reviewed Original Research
2019
Hyperleukocytosis in Cancer Patients
Gowda L, Hosing C. Hyperleukocytosis in Cancer Patients. 2019, 1147-1153. DOI: 10.1007/978-3-319-74588-6_94.Peer-Reviewed Original ResearchTumor lysis syndromeWhite blood cellsDefinitive therapyPeripheral blood white blood cellsBlood white blood cellsSupportive care measuresHigh WBC countSymptomatic hyperleukocytosisLysis syndromeCoagulation abnormalitiesIntravascular coagulationLethal complicationAvoidable complicationsPoor prognosisCancer patientsWBC countCare measuresSymptomatic courseMalignant cloneHyperleukocytosisAggressive natureTherapeutic interventionsBiologic driversComplicationsBlood cellsHyperleukocytosis in Cancer Patients
Gowda L, Hosing C. Hyperleukocytosis in Cancer Patients. 2019, 1-7. DOI: 10.1007/978-3-319-74698-2_94-1.Peer-Reviewed Original ResearchTumor lysis syndromeWhite blood cellsDefinitive therapyPeripheral blood white blood cellsBlood white blood cellsSupportive care measuresHigh WBC countSymptomatic hyperleukocytosisLysis syndromeCoagulation abnormalitiesIntravascular coagulationLethal complicationAvoidable complicationsPoor prognosisCancer patientsWBC countCare measuresSymptomatic courseMalignant cloneHyperleukocytosisAggressive natureTherapeutic interventionsBiologic driversComplicationsBlood cells
1998
Hyperleukocytosis and retinal hemorrhages after chemotherapy and filgrastim administration for peripheral blood progenitor cell mobilization
Salloum E, Stoessel K, Cooper D. Hyperleukocytosis and retinal hemorrhages after chemotherapy and filgrastim administration for peripheral blood progenitor cell mobilization. Bone Marrow Transplantation 1998, 21: 835-837. PMID: 9603411, DOI: 10.1038/sj.bmt.1701090.Peer-Reviewed Original ResearchConceptsPBPC mobilizationRetinal hemorrhagesPeripheral blood progenitor cell mobilizationProgenitor cell mobilizationMantle cell lymphomaFilgrastim administrationPatient's symptomsEarly recognitionCell mobilizationCell lymphomaSymptomsHyperleukocytosisHemorrhageFilgrastimFirst reportMobilizationCyclophosphamideLeukopheresisChemotherapyComplicationsLeukapheresisPatientsLymphomaEtoposideAdministration
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