Online Hydrogen-Deuterium Exchange and a Tandem-Quadrupole Time-of-Flight Mass Spectrometer Coupled with Liquid Chromatography for Metabolite Identification in Drug Metabolism*
Nassar A. Online Hydrogen-Deuterium Exchange and a Tandem-Quadrupole Time-of-Flight Mass Spectrometer Coupled with Liquid Chromatography for Metabolite Identification in Drug Metabolism*. Journal Of Chromatographic Science 2003, 41: 398-404. PMID: 14558931, DOI: 10.1093/chromsci/41.8.398.Peer-Reviewed Original ResearchConceptsMetabolite identificationMobile phaseHydrogen-deuterium (H-D) exchangeH-D exchange processTime-of-flight mass spectrometerDemethylation of methoxy groupsHydroxylation of methyl groupsH-D exchangeHydrogen-deuterium exchangeIdentification of metabolitesLiquid chromatographyMethoxy groupEster groupsMethyl groupMetabolite elucidationMass spectrometerHuman hepatic microsomesD(2)ODrug discoveryDehydrogenationExchange processRetention timeEquilibration timeOxidationNo significant difference
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