2025
Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice
Hoyt L, Liu E, Olson E, Jacobsen D, Siniscalco E, Krier-Burris R, Greenfield K, McBride C, Alfajaro M, Amat J, Zhao Z, Xu L, Philip V, Verma A, Fourati S, Senger D, Zhang L, Bunyavanich S, Glass S, Coffey R, Wilen C, Williams A, Eisenbarth S. Cysteinyl leukotrienes stimulate gut absorption of food allergens to promote anaphylaxis in mice. Science 2025, 389: eadp0240. PMID: 40773557, PMCID: PMC12333546, DOI: 10.1126/science.adp0240.Peer-Reviewed Original ResearchConceptsFood-specific immunoglobulin ESensitivity to anaphylaxisFood-specific IgEResistant C57BL/6 miceFood allergensLife-threatening anaphylaxisStrains of miceGut absorptionOral anaphylaxisSusceptible miceResistant miceC57BL/6 miceCysteinyl leukotrienesAllergen consumptionAllergic sensitizationFood allergyImmunoglobulin EAllergen absorptionAnaphylaxisIntestinal epitheliumMiceIntestinal goblet cellsAllergen transportSynthesis inhibitorGoblet cells
2024
All roads lead to IgA: Mapping the many pathways of IgA induction in the gut
Siniscalco E, Williams A, Eisenbarth S. All roads lead to IgA: Mapping the many pathways of IgA induction in the gut. Immunological Reviews 2024, 326: 66-82. PMID: 39046160, DOI: 10.1111/imr.13369.Peer-Reviewed Original ResearchIgA inductionFood allergyFood-specific IgE.Food-specific IgEAntibody isotypesPrevalence of food allergyT cell helpIncreasing prevalence of food allergyRelease of histamineFoodFood antigensB cellsInduce toleranceAdverse reactionsCommensal bacteriaMast cellsIncreased prevalenceGut immunityIgAGutAllergyAntibodiesIsotypeInductionDOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells.
Williams A, Siniscalco E, Grassmann J, Craft J, Eisenbarth S, Uthaman G. DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. The Journal Of Immunology 2024, 212: 0620_4120-0620_4120. DOI: 10.4049/jimmunol.212.supp.0620.4120.Peer-Reviewed Original ResearchPeanut-specific IgET cellsSpecific IgEFood allergyT Follicular Helper CellsCD4+ T cellsDOCK8-deficient patientsFood-specific IgEPeanut-specific IgE.Human T cellsCells in vitroDifferentiation in vivoSevere food allergyTfh cellsRegulatory populationsOvercome toleranceHelper cellsDeficient patientsSpecific IgE.DOCK8IgE productionSTAT3 mutationsMiceCholera toxinIgE
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